| Literature DB >> 18083093 |
Abstract
Toll-like receptors (TLRs) provoke a profound inflammatory response during host defense and must be controlled in order to avoid autoimmune and inflammatory diseases. In this issue, Rothlin et al. (2007) uncover a complex negative feedback mechanism to limit TLR signaling involving the Tyro3/Axl/Mer (TAM) family of receptor tyrosine kinases, which induce expression of the inhibitory proteins SOCS1 and SOCS3.Entities:
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Year: 2007 PMID： 18083093 DOI： 10.1016/j.cell.2007.11.032
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582