| Literature DB >> 18082956 |
Katja Tenner1, Fatimunnisa Qadri, Bettina Bert, Jörg-Peter Voigt, Michael Bader.
Abstract
Tryptophan hydroxylase 2 (TPH2) is the rate limiting enzyme of serotonin synthesis in the brain. A recently described functional (C1473G) single nucleotide polymorphism in mouse TPH2 resulting in vitro in a strongly decreased enzymatic activity was suspected to be responsible for the observed differences in 5-HT levels and behaviour between mice strains. We bred two substrains of C57BL/6 mice carrying the two isoforms and could show that both exhibit equal TPH activity, brain 5-HT content and behaviour. These data indicate that the distinct behavioural characteristics of mouse strains are not due to differences in TPH2 activity, but to other variations in the genetic background.Entities:
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Year: 2007 PMID： 18082956 DOI： 10.1016/j.neulet.2007.11.012
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046