| Literature DB >> 18082904 |
Sahar Abubucker1, John Martin, Yong Yin, Lucinda Fulton, Shiaw-Pyng Yang, Kym Hallsworth-Pepin, J Spencer Johnston, John Hawdon, James P McCarter, Richard K Wilson, Makedonka Mitreva.
Abstract
Hookworms infect nearly a billion people. The Ancylostoma caninum hookworm of canids is a model for studying human infections and information from its genome coupled with functional genomics and proteomics can accelerate progress towards hookworm control. As a step towards a full-scale A. caninum genome project, we generated 104,000 genome survey sequences (GSSs) and determined the genome size of the canine hookworm. GSSs assembled into 57.6 Mb of unique sequence from a genome that we estimate by flow cytometry of isolated nuclei to be 347 +/- 1.2 Mb, substantially larger than other Rhabditina species. Gene finding identified 5538 genes in the GSS assembly, for a total of 9113 non-redundant A. caninum genes when EST sequences are also considered. Functional classifications of many of the 70% of genes with homology to genes in other species are provided based on gene ontology and KEGG associations and secreted and membrane-bound proteins are also identified.Entities:
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Year: 2007 PMID： 18082904 PMCID： PMC2265417 DOI： 10.1016/j.molbiopara.2007.11.001
Source DB: PubMed Journal: Mol Biochem Parasitol ISSN： 0166-6851 Impact factor: 1.759