BACKGROUND: Visceral adiposity is the major risk factor for paediatric nonalcoholic fatty liver disease. AIMS: Determine the prevalence of nonalcoholic fatty liver disease according to the visceral fat quartile. SUBJECTS: 181 obese adolescents including 113 girls (16.58+/-1.56 years) and 68 boys (16.87+/-1.62 years) were evaluated. METHODS: The inclusion criteria were obesity and post-pubertal stage of Tanner. Visceral fat of obese adolescents was distributed in quartiles after ultrasound nonalcoholic fatty liver disease diagnosis. RESULTS: Nonalcoholic fatty liver disease prevalence was 45.30%. It was observed that 62.07% and 76.47% of girls and boys with nonalcoholic fatty liver disease were found in the 4th quartile. In a multivariate logistic analysis it was observed that only visceral fat remained statistically significant, every 1cm increase in visceral fat was associated with a 1.97 fold (95% CI 1.06-3.66) in boys and 2.08 fold (95% CI 1.38-3.13) in girls increased risk to develop nonalcoholic fatty liver disease. Indeed it was verified a positive correlation between visceral fat, body mass index, insulin levels, homeostasis model assessment insulin resistance index and steatosis degree. CONCLUSIONS: Our findings suggested that the expansion of visceral fat was a determinant factor to increase nonalcoholic fatty liver disease prevalence and the visceral fat measured by ultrasound might be a good predictor to identify risk for nonalcoholic fatty liver disease in obese adolescents. It was confirmed by a stronger correlation between visceral fat and body mass index.
BACKGROUND: Visceral adiposity is the major risk factor for paediatric nonalcoholic fatty liver disease. AIMS: Determine the prevalence of nonalcoholic fatty liver disease according to the visceral fat quartile. SUBJECTS: 181 obese adolescents including 113 girls (16.58+/-1.56 years) and 68 boys (16.87+/-1.62 years) were evaluated. METHODS: The inclusion criteria were obesity and post-pubertal stage of Tanner. Visceral fat of obese adolescents was distributed in quartiles after ultrasound nonalcoholic fatty liver disease diagnosis. RESULTS:Nonalcoholic fatty liver disease prevalence was 45.30%. It was observed that 62.07% and 76.47% of girls and boys with nonalcoholic fatty liver disease were found in the 4th quartile. In a multivariate logistic analysis it was observed that only visceral fat remained statistically significant, every 1cm increase in visceral fat was associated with a 1.97 fold (95% CI 1.06-3.66) in boys and 2.08 fold (95% CI 1.38-3.13) in girls increased risk to develop nonalcoholic fatty liver disease. Indeed it was verified a positive correlation between visceral fat, body mass index, insulin levels, homeostasis model assessment insulin resistance index and steatosis degree. CONCLUSIONS: Our findings suggested that the expansion of visceral fat was a determinant factor to increase nonalcoholic fatty liver disease prevalence and the visceral fat measured by ultrasound might be a good predictor to identify risk for nonalcoholic fatty liver disease in obese adolescents. It was confirmed by a stronger correlation between visceral fat and body mass index.
Authors: Raquel M S Campos; Aline de Piano; Patrícia L da Silva; June Carnier; Priscila L Sanches; Flávia C Corgosinho; Deborah C L Masquio; Marise Lazaretti-Castro; Lila M Oyama; Cláudia M O Nascimento; Lian Tock; Marco Túlio de Mello; Sergio Tufik; Ana R Dâmaso Journal: Endocrine Date: 2012-08 Impact factor: 3.633
Authors: Lian Tock; Ana R Dâmaso; Aline de Piano; June Carnier; Priscila L Sanches; Henrique Manoel Lederman; Regina M Y Ernandes; Marco Túlio de Mello; Sérgio Tufik Journal: J Obes Date: 2010-02-09
Authors: Wagner Luiz do Prado; Aline de Piano; Marise Lazaretti-Castro; Marco Túlio de Mello; Sérgio Garcia Stella; Sergio Tufik; Cláudia Maria Oller do Nascimento; Lila Missae Oyama; Mara Cristina Lofrano; Lian Tock; Danielle Arisa Caranti; Ana Raimunda Dâmaso Journal: J Bone Miner Metab Date: 2009-05-26 Impact factor: 2.626
Authors: Marco Túlio de Mello; Aline de Piano; June Carnier; Priscila de Lima Sanches; Fabíola Alvise Corrêa; Lian Tock; Regina M Y Ernandes; Sérgio Tufik; Ana R Dâmaso Journal: J Clin Hypertens (Greenwich) Date: 2010-11-08 Impact factor: 3.738
Authors: Mara Cristina Lofrano-Prado; Hanna Karen Moreira Antunes; Wagner Luiz do Prado; Aline de Piano; Danielle Arisa Caranti; Lian Tock; June Carnier; Sergio Tufik; Marco Túlio de Mello; Ana R Dâmaso Journal: Health Qual Life Outcomes Date: 2009-07-03 Impact factor: 3.186
Authors: Paula A Monteiro; Jorge Mota; Loreana S Silveira; Suziane U Cayres; Bárbara de Moura M Antunes; Romulo Araujo Fernandes; Ismael F Freitas Journal: BMC Res Notes Date: 2013-03-09