| Literature DB >> 18081874 |
T Toubai1, Y Shono, J Nishihira, M Ibata, J Suigita, N Kato, T Ohkawara, S Tone, K P Lowler, S Ota, J Tanaka, M Asaka, P Reddy, M Imamura.
Abstract
Macrophage migration inhibitory factor (MIF) may play an important role in the pathogenesis of acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT), as MIF plays an important role to regulate the production of tumor necrosis factor-alpha (TNF-alpha), one of the inflammatory cytokines which induces and exacerbates aGVHD. We examined the association between serum MIF levels and aGVHD vs. chronic GVHD (cGVHD) in allo-SCT patients in this study. We found a significant increase in the peak serum MIF (14.46 ng +/- 1.47 ng/ml) at onset in patients that developed aGVHD (n = 23, P = 0.009). We also found that mean serum MIF levels in patients who developed extensive type cGVHD within 6 months (12.58 +/- 2.18 ng/ml, n = 13) were significantly higher than MIF levels before allo-HSCT (7.86 +/- 1.17 ng/ml, n = 19, P = 0.04). Therefore, we speculated that serum MIF levels increase during the active phase of both aGVHD and cGVHD.Entities:
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Year: 2007 PMID： 18081874 DOI： 10.1111/j.1751-553X.2007.01016.x
Source DB: PubMed Journal: Int J Lab Hematol ISSN： 1751-5521 Impact factor: 2.877