Literature DB >> 18079669

[Molecular pharmacogenetics in hospital laboratories in France: current data and future prospects].

D Allorge1, P-H Beaune, L Becquemont, G Bessard, S Bezieau, M Boisdron-Celle, J-C Boyer, F Broly, C-M Dhaneens, X Fonrose, M-C Gagnieu, E Gamelin, C Gozé, E Jacqz-Aigrain, S Loric, M-A Loriot, P Marquet, A Morel, B Namour, G Paintaud, K Peoc'h, N Picard, H Watier, C Verstuyft.   

Abstract

Molecular pharmacogenetic units have recently been established in several hospital laboratories in France. The clinical impact of these units is still limited and numerous problems of organizational, ethical, legal, technical, social and economical nature remain to be resolved. However, an increasing number of these units, a rise in their activities and an enlargement of their scope of application are foreseeable in the future. Ultimately, these units would significantly contribute to limit the public health problem caused by interindividual variabilities in drug effects. In view of these prospects, it seems essential that such hospital activity should be quickly recognised by the authorities and the various health sectors in France. It is also essential that the problems that arise from such pharmacogenetic activities should be considered by the authorities and would profit from the organization of a national network and from financial guarantees.

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Year:  2007        PMID: 18079669     DOI: 10.1016/s0003-4509(07)74196-2

Source DB:  PubMed          Journal:  Ann Pharm Fr        ISSN: 0003-4509


  2 in total

1.  Response to CYP2D6 substrate antidepressants is predicted by a CYP2D6 composite phenotype based on genotype and comedications with CYP2D6 inhibitors.

Authors:  F Gressier; C Verstuyft; P Hardy; L Becquemont; E Corruble
Journal:  J Neural Transm (Vienna)       Date:  2014-07-22       Impact factor: 3.575

2.  Pharmacogenetic-guided glimepiride therapy in type-2 diabetes mellitus: a cost-effectiveness study.

Authors:  Cécile Fokoun; Hassan Serrier; Hugo Rabier; Sylvain Goutelle; Michel Tod; Laurent Bourguignon
Journal:  Pharmacogenomics J       Date:  2021-03-17       Impact factor: 3.550

  2 in total

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