Literature DB >> 18078747

A novel bicyclic hexapeptide, RA-XVIII, from Rubia cordifolia: structure, semi-synthesis, and cytotoxicity.

Ji-Ean Lee1, Yukio Hitotsuyanagi, Ik-Hwi Kim, Tomoyo Hasuda, Koichi Takeya.   

Abstract

A new bicyclic peptide of RA-series, RA-XVIII (3), was isolated from the roots of Rubia cordifolia L. Its structure was established to be a hydroxylated derivative of RA-VII by the semi-synthesis of 3 from deoxybouvardin, and its cytotoxicity against P-388 cells was 0.012 microg/mL.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 18078747     DOI： 10.1016/j.bmcl.2007.11.030

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Cyclopeptide RA-V inhibits angiogenesis by down-regulating ERK1/2 phosphorylation in HUVEC and HMEC-1 endothelial cells.

Authors:  Grace G L Yue; Jun-Ting Fan; Julia K M Lee; Guang-Zhi Zeng; Tina W F Ho; Kwok-Pui Fung; Ping-Chung Leung; Ning-Hua Tan; Clara B S Lau
Journal:  Br J Pharmacol       Date:  2011-12       Impact factor: 8.739

Review 2.  Plant antimicrobial peptides as potential anticancer agents.

Authors:  Jaquelina Julia Guzmán-Rodríguez; Alejandra Ochoa-Zarzosa; Rodolfo López-Gómez; Joel E López-Meza
Journal:  Biomed Res Int       Date:  2015-03-01       Impact factor: 3.411

3.  Rubipodanin A, the First Natural N-Desmonomethyl Rubiaceae-Type Cyclopeptide from Rubia podantha, Indicating an Important Role of the N9-Methyl Group in the Conformation and Bioactivity.

Authors:  Zhe Wang; Si-Meng Zhao; Li-Mei Zhao; Xiao-Qiang Chen; Guang-Zhi Zeng; Ning-Hua Tan
Journal:  PLoS One       Date:  2015-12-22       Impact factor: 3.240

Review 4.  A comprehensive review of Rubia cordifolia L.: Traditional uses, phytochemistry, pharmacological activities, and clinical applications.

Authors:  Min Wen; Qi Chen; Wang Chen; Jing Yang; Xiaogang Zhou; Chunxiang Zhang; Anguo Wu; Jia Lai; Jianping Chen; Qibing Mei; Shuo Yang; Cai Lan; Jianming Wu; Feihong Huang; Long Wang
Journal:  Front Pharmacol       Date:  2022-09-09       Impact factor: 5.988

5.  Structural and bioactive studies of terpenes and cyclopeptides from the Genus Rubia.

Authors:  Kuo Xu; Penglong Wang; Bin Yuan; Yatao Cheng; Qiang Li; Haimin Lei
Journal:  Chem Cent J       Date:  2013-05-04       Impact factor: 4.215

6.  Rubiacordone A: a new anthraquinone glycoside from the roots of Rubia cordifolia.

Authors:  Xiang Li; Zhi Liu; Yun Chen; Li-Juan Wang; Yi-Nan Zheng; Guang-Zhi Sun; Chang-Chun Ruan
Journal:  Molecules       Date:  2009-01-23       Impact factor: 4.411

Review 7.  Design and synthesis of analogues of RA-VII-an antitumor bicyclic hexapeptide from Rubiae radix.

Authors:  Yukio Hitotsuyanagi
Journal:  J Nat Med       Date:  2021-07-10       Impact factor: 2.343
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.