Tranum Kaur1, C M Pathak, P Pandhi, K L Khanduja. 1. Department of Biophysics, Post Graduate Institute of Medical Education and Research, Chandigarh, India. tranumsidhu@yahoo.com
Abstract
OBJECTIVE: To study the effects of green tea extract administration on age-related cognition in young and old male Wistar rats. METHODS: Young and old rats were orally administered 0.5% green tea extract for a period of eight weeks and were evaluated by passive avoidance, elevated maze plus paradigm and changes in acetylcholinesterase activity. RESULTS: Treatment of young and old rats with the extract resulted in no significant difference in performance on the rota rod treadmill test/righting reflex time. Green tea extract significantly improved learning and memory in older rats, with increased retention latency to enter difference in passive avoidance test. In the elevated maze test, green tea treatment resulted in significantly more number of entries in the enclosed arm by the young and old rats. Decline in acetylcholinesterase activity was observed in the cerebrum of green tea treated old rats in comparison to the green tea treated young rats. CONCLUSION: Green tea extract administration is effective in enhancing learning and memory in aged rats, and hence, may serve useful in reversing age-related deficits.
OBJECTIVE: To study the effects of green tea extract administration on age-related cognition in young and old male Wistar rats. METHODS: Young and old rats were orally administered 0.5% green tea extract for a period of eight weeks and were evaluated by passive avoidance, elevated maze plus paradigm and changes in acetylcholinesterase activity. RESULTS: Treatment of young and old rats with the extract resulted in no significant difference in performance on the rota rod treadmill test/righting reflex time. Green tea extract significantly improved learning and memory in older rats, with increased retention latency to enter difference in passive avoidance test. In the elevated maze test, green tea treatment resulted in significantly more number of entries in the enclosed arm by the young and old rats. Decline in acetylcholinesterase activity was observed in the cerebrum of green tea treated old rats in comparison to the green tea treated young rats. CONCLUSION: Green tea extract administration is effective in enhancing learning and memory in aged rats, and hence, may serve useful in reversing age-related deficits.
Authors: Giselli Scaini; Natália de Rochi; Isabela C Jeremias; Pedro F Deroza; Alexandra I Zugno; Talita C B Pereira; Giovanna M T Oliveira; Luiza W Kist; Maurício R Bogo; Patrícia F Schuck; Gustavo C Ferreira; Emilio L Streck Journal: Mol Neurobiol Date: 2012-02-12 Impact factor: 5.590
Authors: Catarina Rendeiro; David Vauzour; Rebecca J Kean; Laurie T Butler; Marcus Rattray; Jeremy P E Spencer; Claire M Williams Journal: Psychopharmacology (Berl) Date: 2012-05-09 Impact factor: 4.530
Authors: Catarina Rendeiro; Andrew Foley; Vera C Lau; Rebecca Ring; Ana Rodriguez-Mateos; David Vauzour; Claire M Williams; Ciaran Regan; Jeremy P E Spencer Journal: Neuropharmacology Date: 2013-12-11 Impact factor: 5.250
Authors: Catarina Rendeiro; David Vauzour; Marcus Rattray; Pierre Waffo-Téguo; Jean Michel Mérillon; Laurie T Butler; Claire M Williams; Jeremy P E Spencer Journal: PLoS One Date: 2013-05-28 Impact factor: 3.240
Authors: André Schmidt; Felix Hammann; Bettina Wölnerhanssen; Anne Christin Meyer-Gerspach; Jürgen Drewe; Christoph Beglinger; Stefan Borgwardt Journal: Psychopharmacology (Berl) Date: 2014-03-19 Impact factor: 4.530