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Literature DB >> 18078344

New cytotoxic 14-membered macrolides from marine-derived fungus Aspergillus ostianus.

Keijiro Kito¹, Ryuhei Ookura, Sanae Yoshida, Michio Namikoshi, Takashi Ooi, Takenori Kusumi.

Abstract

Three new 14-membered macrolides, named aspergillides A, B, and C (1, 5, and 7), were isolated from marine-derived fungus Aspergillus ostianus strain 01F313, cultured in a medium composed of bromine-modified artificial seawater. The structures of the new compounds were determined by analyses of 1D and 2D NMR spectra. Their absolute configurations were elucidated by the modified Mosher's method and chemical conversions. The new compounds showed cytotoxic activity against mouse lymphocytic leukemia cells (L1210).

Entities: Chemical Disease Species

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Year: 2007 PMID： 18078344 DOI： 10.1021/ol702598q

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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Cited

12 in total

Review 1. Survey of marine natural product structure revisions: a synergy of spectroscopy and chemical synthesis.

Authors: Takashi L Suyama; William H Gerwick; Kerry L McPhail
Journal: Bioorg Med Chem Date: 2011-06-12 Impact factor: 3.641

2. Isolation, structural elucidation, and absolute stereochemistry of enigmazole A, a cytotoxic phosphomacrolide from the Papua New Guinea marine sponge Cinachyrella enigmatica.

Authors: Naoya Oku; Kentaro Takada; Richard W Fuller; Jennifer A Wilson; Megan L Peach; Lewis K Pannell; James B McMahon; Kirk R Gustafson
Journal: J Am Chem Soc Date: 2010-08-04 Impact factor: 15.419

New cytotoxic 14-membered macrolides from marine-derived fungus Aspergillus ostianus.

Review 1. Survey of marine natural product structure revisions: a synergy of spectroscopy and chemical synthesis.

2. Isolation, structural elucidation, and absolute stereochemistry of enigmazole A, a cytotoxic phosphomacrolide from the Papua New Guinea marine sponge Cinachyrella enigmatica.

3. Achmatowicz Reaction and its Application in the Syntheses of Bioactive Molecules.

4. Transition-metal-catalyzed synthesis of aspergillide B: an alkyne addition strategy.

Review 5. Marine drugs from sponge-microbe association--a review.

6. Enantioselective formal total synthesis of (+)-aspergillide C.

7. Investigation of Marine-Derived Fungal Diversity and Their Exploitable Biological Activities.

8. A carbohydrate approach for the formal total synthesis of (-)-aspergillide C.

9. Bioactive phenylalanine derivatives and cytochalasins from the soft coral-derived fungus, Aspergillus elegans.

Review 10. A survey of marine natural compounds and their derivatives with anti-cancer activity reported in 2011.