[Comparative study of the effects of new fluorine-containing pinacidyl analogs on bladder contractile function and vessel tone].

The effects of four new fluorine-containing pinacidyl analogs (FPs) on the bladder contractile function in vitro and in vivo, and on the vessel tone in vitro were examined. All the four drugs produced a concentration-dependent relaxation of isolated rat detrusor strips and isolated aorta rings. The contractility inhibition effect of compound FP-5 was decreased by preliminary glibenclamide perfusion. This compound also effectively inhibited bladder contractility function in vivo.