Literature DB >> 18077718

H5-type influenza virus hemagglutinin is functionally recognized by the natural killer-activating receptor NKp44.

Joanna W Ho1, Oren Hershkovitz, Malik Peiris, Alon Zilka, Ahuva Bar-Ilan, Beatrice Nal, Kid Chu, Mateusz Kudelko, Yiu Wing Kam, Hagit Achdout, Michal Mandelboim, Ralf Altmeyer, Ofer Mandelboim, Roberto Bruzzone, Angel Porgador.   

Abstract

Antiviral immune defenses involve natural killer (NK) cells. We previously showed that the NK-activating receptor NKp44 is involved in the functional recognition of H1-type influenza virus strains by NK cells. In the present study, we investigated the interaction of NKp44 and the hemagglutinin of a primary influenza virus H5N1 isolate. Here we show that recombinant NKp44 recognizes H5-expressing cells and specifically interacts with soluble H5 hemagglutinin. H5-pseudotyped lentiviral particles bind to NK cells expressing NKp44. Following interaction with target cells expressing H5, pseudotyped lentiviral particles, or membrane-associated H5, NK cells show NKp44-mediated induced activity. These findings indicate that NKp44-H5 interactions induce functional NK activation.

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Year:  2007        PMID： 18077718      PMCID： PMC2258730          DOI： 10.1128/JVI.02065-07

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  23 in total

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2.  Severe herpesvirus infections in an adolescent without natural killer cells.

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6.  Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus.

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10.  Evolution of H5N1 avian influenza viruses in Asia.

Authors: 
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  38 in total

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Review 7.  Switch from protective to adverse inflammation during influenza: viral determinants and hemostasis are caught as culprits.

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10.  Calcineurin-dependent lytic granule exocytosis in NK-92 natural killer cells.

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