Literature DB >> 18077669

Moderate reduction of gamma-secretase: is there a therapeutic sweet spot?

Se Hoon Choi1, Eric Norstrom.   

Abstract

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Year:  2007        PMID： 18077669      PMCID： PMC6673637          DOI： 10.1523/JNEUROSCI.4821-07.2007

Source DB:  PubMed          Journal:  J Neurosci        ISSN： 0270-6474            Impact factor:   6.167


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  2 in total

1.  gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease.

Authors:  Lutgarde Serneels; Jérôme Van Biervliet; Katleen Craessaerts; Tim Dejaegere; Katrien Horré; Tine Van Houtvin; Hermann Esselmann; Sabine Paul; Martin K Schäfer; Oksana Berezovska; Bradley T Hyman; Ben Sprangers; Raf Sciot; Lieve Moons; Mathias Jucker; Zhixiang Yang; Patrick C May; Eric Karran; Jens Wiltfang; Rudi D'Hooge; Bart De Strooper
Journal:  Science       Date:  2009-03-19       Impact factor: 47.728

2.  Discovery of a Tetrahydrobenzisoxazole Series of γ-Secretase Modulators.

Authors:  Zhiqiang Zhao; Dmitri A Pissarnitski; Xianhai Huang; Anandan Palani; Zhaoning Zhu; William J Greenlee; Lynn A Hyde; Lixin Song; Giuseppe Terracina; Lili Zhang; Eric M Parker
Journal:  ACS Med Chem Lett       Date:  2017-09-19       Impact factor: 4.345
  2 in total

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