BACKGROUND: Obesity is increasing rapidly among women all over the world. Obesity is a known risk factor for subfertility due to anovulation, but it is unknown whether obesity also affects spontaneous pregnancy chances in subfertile, ovulatory women. METHODS: We evaluated whether obesity affected the chance of a spontaneous pregnancy in a prospectively assembled cohort of 3029 consecutive subfertile couples. Women had to be ovulatory and had to have at least one patent tube, whereas men had to have a normal semen analysis. Time to spontaneous ongoing pregnancy within 12 months was the primary endpoint. RESULTS: The probability of a spontaneous pregnancy declined linearly with a body mass index (BMI) over 29 kg/m(2). Corrected for possible related factors, women with a high BMI had a 4% lower pregnancy rate per kg/m(2) increase [hazard ratio: 0.96 (95% CI 0.91-0.99)]. CONCLUSIONS: These results indicate that obesity is associated with lower pregnancy rates in subfertile ovulatory women.
BACKGROUND:Obesity is increasing rapidly among women all over the world. Obesity is a known risk factor for subfertility due to anovulation, but it is unknown whether obesity also affects spontaneous pregnancy chances in subfertile, ovulatory women. METHODS: We evaluated whether obesity affected the chance of a spontaneous pregnancy in a prospectively assembled cohort of 3029 consecutive subfertile couples. Women had to be ovulatory and had to have at least one patent tube, whereas men had to have a normal semen analysis. Time to spontaneous ongoing pregnancy within 12 months was the primary endpoint. RESULTS: The probability of a spontaneous pregnancy declined linearly with a body mass index (BMI) over 29 kg/m(2). Corrected for possible related factors, women with a high BMI had a 4% lower pregnancy rate per kg/m(2) increase [hazard ratio: 0.96 (95% CI 0.91-0.99)]. CONCLUSIONS: These results indicate that obesity is associated with lower pregnancy rates in subfertile ovulatory women.
Authors: Lia A Bernardi; Mercedes R Carnethon; Peter J de Chavez; Deborah E Ikhena; Lisa M Neff; Donna D Baird; Erica E Marsh Journal: Obesity (Silver Spring) Date: 2016-12-07 Impact factor: 5.002
Authors: Meike A Q Mutsaerts; Henk Groen; Nancy C W ter Bogt; Johanna H T Bolster; Jolande A Land; Wanda J E Bemelmans; Walter K H Kuchenbecker; Peter G A Hompes; Nick S Macklon; Ronald P Stolk; Fulco van der Veen; Jacques W M Maas; Nicole F Klijn; Eugenie M Kaaijk; Gerrit J E Oosterhuis; Peter X J M Bouckaert; Jaap M Schierbeek; Yvonne M van Kasteren; Annemiek W Nap; Frank J Broekmans; Egbert A Brinkhuis; Carolien A M Koks; Jan M Burggraaff; Adrienne S Blankhart; Denise A M Perquin; Marie H Gerards; Robert J A B Mulder; Ed T C M Gondrie; Ben W J Mol; Annemieke Hoek Journal: BMC Womens Health Date: 2010-06-25 Impact factor: 2.809
Authors: Ellen A Nohr; Nicholas J Timpson; Camilla S Andersen; George Davey Smith; Jørn Olsen; Thorkild I A Sørensen Journal: PLoS One Date: 2009-12-24 Impact factor: 3.240