| Literature DB >> 18077165 |
Nuno Vale1, Margaret S Collins, Jiri Gut, Ricardo Ferraz, Philip J Rosenthal, Melanie T Cushion, Rui Moreira, Paula Gomes.
Abstract
A series of primaquine-derived imidazolidin-4-ones were screened for their in vitro activity against Pneumocystis carinii and Plasmodium falciparum W2 strain. Most compounds were active against P. carinii above 10 microg/mL and displayed slight to marked activity. The imidazolidin-4-ones most active against P. carinii were also those most active antiplasmodial agents, in the muM range. One of the tested imidazolidin-4-ones was slightly more active than the parent primaquine and may represent a lead compound for the development of novel anti-P. carinii 8-aminoquinolines with increased stability and resistance to metabolic inactivation.Entities:
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Year: 2007 PMID： 18077165 DOI： 10.1016/j.bmcl.2007.11.105
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823