Literature DB >> 18077006

Stem cells ameliorate EAE via an indoleamine 2,3-dioxygenase (IDO) mechanism.

Mariola Matysiak1, Mariusz Stasiołek, Wojciech Orłowski, Anna Jurewicz, Szymon Janczar, Cedric S Raine, Krzysztof Selmaj.   

Abstract

Syngeneic, pluripotent Lin(-)Sca1(+) bone marrow stem cells (SC), transferred to mice with experimental autoimmune encephalomyelitis, a model of multiple sclerosis, enhanced recovery, prevented relapses and promoted myelin repair. SC-treated mice showed elevated interferon-gamma production and induction of indoleamine 2,3-dioxygenase (IDO) in CD11c(+) dendritic cells (DC). IDO induction was specific since in the presence of IDO-producing CD11c(+) DC, PLP stimulated T cell proliferation was inhibited and the IDO-inhibitor, 1-MT, abrogated the SC effect. Relapse prevention during chronic disease correlated with decreased responsiveness to PLP(178-191) and MBP(85-99). Thus, pluripotent SC induce IDO in DC leading to inhibition of antigen reactivity and spreading in EAE.

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Year:  2008        PMID： 18077006      PMCID： PMC2681256          DOI： 10.1016/j.jneuroim.2007.07.025

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  37 in total

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Authors:  B Seshi; S Kumar; D Sellers
Journal:  Blood Cells Mol Dis       Date:  2000-06       Impact factor: 3.039

2.  From marrow to brain: expression of neuronal phenotypes in adult mice.

Authors:  T R Brazelton; F M Rossi; G I Keshet; H M Blau
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3.  Neural precursors attenuate autoimmune encephalomyelitis by peripheral immunosuppression.

Authors:  Ofira Einstein; Nina Fainstein; Ilan Vaknin; Rachel Mizrachi-Kol; Etti Reihartz; Nikolaos Grigoriadis; Iris Lavon; Michal Baniyash; Hans Lassmann; Tamir Ben-Hur
Journal:  Ann Neurol       Date:  2007-03       Impact factor: 10.422

4.  Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis.

Authors:  Stefano Pluchino; Angelo Quattrini; Elena Brambilla; Angela Gritti; Giuliana Salani; Giorgia Dina; Rossella Galli; Ubaldo Del Carro; Stefano Amadio; Alessandra Bergami; Roberto Furlan; Giancarlo Comi; Angelo L Vescovi; Gianvito Martino
Journal:  Nature       Date:  2003-04-17       Impact factor: 49.962

5.  Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis.

Authors:  Ezio Gerdoni; Barbara Gallo; Simona Casazza; Silvia Musio; Ivan Bonanni; Enrico Pedemonte; Renato Mantegazza; Francesco Frassoni; Gianluigi Mancardi; Rosetta Pedotti; Antonio Uccelli
Journal:  Ann Neurol       Date:  2007-03       Impact factor: 10.422

6.  Heterogeneity among human bone marrow-derived mesenchymal stem cells and neural progenitor cells.

Authors:  Wichard Vogel; Frank Grünebach; Conrad A Messam; Lothar Kanz; Wolfram Brugger; Hans-Jörg Bühring
Journal:  Haematologica       Date:  2003-02       Impact factor: 9.941

7.  Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis.

Authors:  C Q Chu; S Wittmer; D K Dalton
Journal:  J Exp Med       Date:  2000-07-03       Impact factor: 14.307

8.  Interferon gamma is required for activation-induced death of T lymphocytes.

Authors:  Yosef Refaeli; Luk Van Parijs; Stephen I Alexander; Abul K Abbas
Journal:  J Exp Med       Date:  2002-10-07       Impact factor: 14.307

9.  Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites.

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10.  Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase.

Authors:  Guido Frumento; Rita Rotondo; Michela Tonetti; Gianluca Damonte; Umberto Benatti; Giovanni Battista Ferrara
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  23 in total

1.  Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation.

Authors:  Giada Mondanelli; Alice Coletti; Francesco Antonio Greco; Maria Teresa Pallotta; Ciriana Orabona; Alberta Iacono; Maria Laura Belladonna; Elisa Albini; Eleonora Panfili; Francesca Fallarino; Marco Gargaro; Giorgia Manni; Davide Matino; Agostinho Carvalho; Cristina Cunha; Patricia Maciel; Massimiliano Di Filippo; Lorenzo Gaetani; Roberta Bianchi; Carmine Vacca; Ioana Maria Iamandii; Elisa Proietti; Francesca Boscia; Lucio Annunziato; Maikel Peppelenbosch; Paolo Puccetti; Paolo Calabresi; Antonio Macchiarulo; Laura Santambrogio; Claudia Volpi; Ursula Grohmann
Journal:  Proc Natl Acad Sci U S A       Date:  2020-02-05       Impact factor: 11.205

Review 2.  Dendritic cells, indoleamine 2,3 dioxygenase and acquired immune privilege.

Authors:  Lei Huang; Babak Baban; Burles A Johnson; Andrew L Mellor
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3.  IDO1 and TGF-β Mediate Protective Effects of IFN-α in Antigen-Induced Arthritis.

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Journal:  J Immunol       Date:  2016-09-19       Impact factor: 5.422

Review 4.  The role of kynurenines in the pathomechanism of amyotrophic lateral sclerosis and multiple sclerosis: therapeutic implications.

Authors:  Judit Füvesi; Cecilia Rajda; Krisztina Bencsik; József Toldi; László Vécsei
Journal:  J Neural Transm (Vienna)       Date:  2012-01-19       Impact factor: 3.575

Review 5.  Targeting the immunoregulatory indoleamine 2,3 dioxygenase pathway in immunotherapy.

Authors:  Burles A Johnson; Babak Baban; Andrew L Mellor
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Review 6.  The importance of NAD in multiple sclerosis.

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7.  Mouse mesenchymal stem cells suppress antigen-specific TH cell immunity independent of indoleamine 2,3-dioxygenase 1 (IDO1).

Authors:  Tobias V Lanz; Christiane A Opitz; Peggy P Ho; Ankur Agrawal; Christian Lutz; Michael Weller; Andrew L Mellor; Lawrence Steinman; Wolfgang Wick; Michael Platten
Journal:  Stem Cells Dev       Date:  2010-05       Impact factor: 3.272

8.  Therapy of experimental type 1 diabetes by isolated Sertoli cell xenografts alone.

Authors:  Francesca Fallarino; Giovanni Luca; Mario Calvitti; Francesca Mancuso; Claudio Nastruzzi; Maria C Fioretti; Ursula Grohmann; Ennio Becchetti; Anne Burgevin; Roland Kratzer; Peter van Endert; Louis Boon; Paolo Puccetti; Riccardo Calafiore
Journal:  J Exp Med       Date:  2009-10-12       Impact factor: 14.307

9.  Human mesenchymal stem cells abrogate experimental allergic encephalomyelitis after intraperitoneal injection, and with sparse CNS infiltration.

Authors:  David Gordon; Gordana Pavlovska; Colin P Glover; James B Uney; David Wraith; Neil J Scolding
Journal:  Neurosci Lett       Date:  2008-10-17       Impact factor: 3.046

Review 10.  How stem cells speak with host immune cells in inflammatory brain diseases.

Authors:  Stefano Pluchino; Chiara Cossetti
Journal:  Glia       Date:  2013-04-30       Impact factor: 7.452
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