| Literature DB >> 18076567 |
Junko Kanoh1, Mitsuhiro Yanagida.
Abstract
A recent paper (Hayashi et al. 2007) in this issue of Genes to Cells shows that the fission yeast Schizosaccharomyces pombe Tel2, a homologue of mammalian/worm CLK2/Clk-2/Rad-5, physically interacts with all the phosphoinositide 3-kinase-related kinases (PIKKs) that include Rad3/Tel1 (ATR/ATM homologues), Tor1/Tor2 (TOR kinases) and Tra1/Tra2 (TRRAP homologues), raising the possibility that Tel2 family proteins link various PIKK-related cellular processes by interacting with PIKK family proteins. In this minireview, implications and impact of the findings, and a possibility that PIKKs are functionally related through Tel2, are discussed.Entities:
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Year: 2007 PMID： 18076567 DOI： 10.1111/j.1365-2443.2007.01142.x
Source DB: PubMed Journal: Genes Cells ISSN： 1356-9597 Impact factor: 1.891