Literature DB >> 18076177

Highly chemoselective metal-free reduction of tertiary amides.

Guillaume Barbe1, André B Charette.   

Abstract

This communication describes the chemoselective metal-free reduction of tertiary amides to the corresponding amines. Hantzsch ester is used as a mild reducing agent for the reduction of trifluoromethanesulfonic anhydride activated amides providing the tertiary amines with high functional group tolerance.

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Year:  2007        PMID： 18076177     DOI： 10.1021/ja077463q

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  20 in total

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8.  Chemo- and Stereoselective Transition-Metal-Free Amination of Amides with Azides.

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9.  Highly chemoselective reduction of amides (primary, secondary, tertiary) to alcohols using SmI2/amine/H2O under mild conditions.

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