BACKGROUND: Infantile hydrocephalus is a common congenital problem. Functional and behavioral disturbances associated with hydrocephalus may be due to altered neurotransmitters in the brain. The role of neurotransmitters has been established in various psychiatric and neurological conditions. Therefore, we decided to study the role of 5-hydroxy indoleacetic acid (5-HIAA) and homovanillic acid (HVA) in cerebrospinal fluid (CSF) of hydrocephalic patients as diagnostic and prognostic marker. MATERIALS AND METHODS: Ventricular CSF samples were taken from hydrocephalic patients peroperatively and at days 7 & 30. Control CSF samples were taken from nonhydrocephalic patients operated for other conditions. Samples were analyzed for 5-HIAA and HVA, and results were obtained accordingly. RESULTS: Values of 5-HIAA and HVA showed a highly significant decrease after shunt insertion. No significant difference in values of 5-HIAA and HVA were observed in relation to age and duration of disease. The CSF ventriculo-lumbar gradient for both 5-HIAA and HVA done in six patients was statistically significant only in the noncommunicating group. CONCLUSION: Both the neurotransmitter metabolites 5-HIAA and HVA are found to be significantly high in the hydrocephalus, but 5-HIAA is a more sensitive parameter. These markers levels decrease after shunt insertion. Thus, estimation of these metabolites could be valuable markers for its diagnosis and follow-up.
BACKGROUND:Infantile hydrocephalus is a common congenital problem. Functional and behavioral disturbances associated with hydrocephalus may be due to altered neurotransmitters in the brain. The role of neurotransmitters has been established in various psychiatric and neurological conditions. Therefore, we decided to study the role of 5-hydroxy indoleacetic acid (5-HIAA) and homovanillic acid (HVA) in cerebrospinal fluid (CSF) of hydrocephalic patients as diagnostic and prognostic marker. MATERIALS AND METHODS: Ventricular CSF samples were taken from hydrocephalic patients peroperatively and at days 7 & 30. Control CSF samples were taken from nonhydrocephalic patients operated for other conditions. Samples were analyzed for 5-HIAA and HVA, and results were obtained accordingly. RESULTS: Values of 5-HIAA and HVA showed a highly significant decrease after shunt insertion. No significant difference in values of 5-HIAA and HVA were observed in relation to age and duration of disease. The CSF ventriculo-lumbar gradient for both 5-HIAA and HVA done in six patients was statistically significant only in the noncommunicating group. CONCLUSION: Both the neurotransmitter metabolites 5-HIAA and HVA are found to be significantly high in the hydrocephalus, but 5-HIAA is a more sensitive parameter. These markers levels decrease after shunt insertion. Thus, estimation of these metabolites could be valuable markers for its diagnosis and follow-up.
Authors: S R Bareggi; M Porta; A Selenati; B M Assael; G Calderini; M Collice; M Rossanda; P L Morselli Journal: Eur Neurol Date: 1975 Impact factor: 1.710
Authors: M Porta; S R Bareggi; M Collice; B M Assael; A Selenati; G Calderini; M Rossanda; P L Morselli Journal: Eur Neurol Date: 1975 Impact factor: 1.710
Authors: S Smirne; M Franceschi; G Truci; M Camerlingo; R Pirola; L Ferini-Strambi; S R Bareggi Journal: Stroke Date: 1985 Nov-Dec Impact factor: 7.914
Authors: Ingvar J Rognum; Hoa Tran; Elisabeth A Haas; Keith Hyland; David S Paterson; Robin L Haynes; Kevin G Broadbelt; Brian J Harty; Othon Mena; Henry F Krous; Hannah C Kinney Journal: J Neuropathol Exp Neurol Date: 2014-02 Impact factor: 3.685
Authors: David D Limbrick; Brandon Baksh; Clinton D Morgan; Gakwaya Habiyaremye; James P McAllister; Terrie E Inder; Deanna Mercer; David M Holtzman; Jennifer Strahle; Michael J Wallendorf; Diego M Morales Journal: PLoS One Date: 2017-02-17 Impact factor: 3.240