Literature DB >> 18075309

Multiple kinases and system robustness: a link between Cdc37 and genome integrity.

Avrom J Caplan, Avi Ma'ayan, Ian M Willis.   

Abstract

We identified 38 genes as having a genetic interaction with a mutant form of the kinase specific chaperone, Cdc37, using a genome-wide synthetic screening approach. The identified genes included a sub-network of highly interacting genes enriched for functions in genome integrity and comprising multiple components of several discrete molecular machines. A network analysis approach related these machines to a small group of cell cycle checkpoint kinases.

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Year:  2007        PMID： 18075309      PMCID： PMC3045565          DOI： 10.4161/cc.6.24.5147

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  15 in total

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Authors:  S Wickner; M R Maurizi; S Gottesman
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Review 2.  Cdc37 goes beyond Hsp90 and kinases.

Authors:  Morag MacLean; Didier Picard
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3.  Cdc37 is a molecular chaperone with specific functions in signal transduction.

Authors:  Y Kimura; S L Rutherford; Y Miyata; I Yahara; B C Freeman; L Yue; R I Morimoto; S Lindquist
Journal:  Genes Dev       Date:  1997-07-15       Impact factor: 11.361

Review 4.  HSP90 and the chaperoning of cancer.

Authors:  Luke Whitesell; Susan L Lindquist
Journal:  Nat Rev Cancer       Date:  2005-10       Impact factor: 60.716

5.  Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone.

Authors:  Rongmin Zhao; Mike Davey; Ya-Chieh Hsu; Pia Kaplanek; Amy Tong; Ainslie B Parsons; Nevan Krogan; Gerard Cagney; Duy Mai; Jack Greenblatt; Charles Boone; Andrew Emili; Walid A Houry
Journal:  Cell       Date:  2005-03-11       Impact factor: 41.582

6.  The Hsp90 co-chaperones Cdc37 and Sti1 interact physically and genetically.

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Journal:  Biol Chem       Date:  2002-09       Impact factor: 3.915

7.  A positive feedback loop between protein kinase CKII and Cdc37 promotes the activity of multiple protein kinases.

Authors:  Sricharan Bandhakavi; Richard O McCann; David E Hanna; Claiborne V C Glover
Journal:  J Biol Chem       Date:  2002-11-14       Impact factor: 5.157

8.  Physical interaction of Cdc28 with Cdc37 in Saccharomyces cerevisiae.

Authors:  M Mort-Bontemps-Soret; C Facca; G Faye
Journal:  Mol Genet Genomics       Date:  2002-05-09       Impact factor: 3.291

Review 9.  Possible effects of early treatments of hsp90 inhibitors on preventing the evolution of drug resistance to other anti-cancer drugs.

Authors:  Li Xiao; Parsa Rasouli; Douglas M Ruden
Journal:  Curr Med Chem       Date:  2007       Impact factor: 4.740

10.  The Cdc37 protein kinase-binding domain is sufficient for protein kinase activity and cell viability.

Authors:  Paul Lee; Jie Rao; Albert Fliss; Emy Yang; Stephen Garrett; Avrom J Caplan
Journal:  J Cell Biol       Date:  2002-12-23       Impact factor: 10.539
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  8 in total

Review 1.  Targeting the oncogene and kinome chaperone CDC37.

Authors:  Phillip J Gray; Thomas Prince; Jinrong Cheng; Mary Ann Stevenson; Stuart K Calderwood
Journal:  Nat Rev Cancer       Date:  2008-05-30       Impact factor: 60.716

Review 2.  Approaches for defining the Hsp90-dependent proteome.

Authors:  Steven D Hartson; Robert L Matts
Journal:  Biochim Biophys Acta       Date:  2011-08-27

Review 3.  Cdc37 as a co-chaperone to Hsp90.

Authors:  Stuart K Calderwood
Journal:  Subcell Biochem       Date:  2015

4.  HSP90/70 chaperones are required for rapid nucleosome removal upon induction of the GAL genes of yeast.

Authors:  Monique Floer; Gene O Bryant; Mark Ptashne
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-19       Impact factor: 11.205

5.  Ubr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteins.

Authors:  Nadinath B Nillegoda; Maria A Theodoraki; Atin K Mandal; Katie J Mayo; Hong Yu Ren; Rasheda Sultana; Kenneth Wu; Jill Johnson; Douglas M Cyr; Avrom J Caplan
Journal:  Mol Biol Cell       Date:  2010-05-12       Impact factor: 4.138

Review 6.  Alternate strategies of Hsp90 modulation for the treatment of cancer and other diseases.

Authors:  Gary E L Brandt; Brian S J Blagg
Journal:  Curr Top Med Chem       Date:  2009       Impact factor: 3.295

Review 7.  The Hsp70-Hsp90 go-between Hop/Stip1/Sti1 is a proteostatic switch and may be a drug target in cancer and neurodegeneration.

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Review 8.  The Potential of Hsp90 in Targeting Pathological Pathways in Cardiac Diseases.

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Journal:  J Pers Med       Date:  2021-12-16
  8 in total

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