BACKGROUND/AIMS AND METHODS: Perseveration is common in Alzheimer's disease (AD). We document the type and quantitative burden of perseveration as cognitive decline progresses from normal aging (n = 30) through mild AD (n = 20) to moderate AD (n = 20) by administering a semantic verbal fluency task. RESULTS: We found perseveration to increase significantly with increasing severity of AD and different types of perseveration that distinguish the subject groups in a statistically significant manner. Recurrent and continuous perseverations appear early in AD. As the disease progresses in severity into moderate stage, the number of recurrent and continuous perseverations increases, and stuck-in-set perseverations emerge. CONCLUSION: The different types of perseveration are likely to reflect the progressive deterioration of different brain regions in AD. Copyright (c) 2007 S. Karger AG, Basel.
BACKGROUND/AIMS AND METHODS: Perseveration is common in Alzheimer's disease (AD). We document the type and quantitative burden of perseveration as cognitive decline progresses from normal aging (n = 30) through mild AD (n = 20) to moderate AD (n = 20) by administering a semantic verbal fluency task. RESULTS: We found perseveration to increase significantly with increasing severity of AD and different types of perseveration that distinguish the subject groups in a statistically significant manner. Recurrent and continuous perseverations appear early in AD. As the disease progresses in severity into moderate stage, the number of recurrent and continuous perseverations increases, and stuck-in-set perseverations emerge. CONCLUSION: The different types of perseveration are likely to reflect the progressive deterioration of different brain regions in AD. Copyright (c) 2007 S. Karger AG, Basel.
Authors: Geon Ha Kim; Sang Won Seo; Kihyo Jung; Oh-Hun Kwon; Hunki Kwon; Jong Hun Kim; Jee Hoon Roh; Min-Jeong Kim; Byung Hwa Lee; Doo Sang Yoon; Jung Won Hwang; Jong Min Lee; Jee Hyang Jeong; Heecheon You; Kenneth M Heilman; Duk L Na Journal: J Neurol Date: 2015-10-29 Impact factor: 4.849
Authors: Seija Pekkala; Mira Goral; Jungmoon Hyun; Loraine K Obler; Timo Erkinjuntti; Martin L Albert Journal: Clin Linguist Phon Date: 2009-06 Impact factor: 1.346
Authors: Eosu Kim; Matthew A White; Benjamin U Phillips; Laura Lopez-Cruz; Hyunjeong Kim; Christopher J Heath; Jong Eun Lee; Lisa M Saksida; Jemeen Sreedharan; Timothy J Bussey Journal: Transl Psychiatry Date: 2020-11-04 Impact factor: 6.222