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Literature DB >> 18073444

Synthetic lethal interactions identify phenotypic "interologs" of the spindle assembly checkpoint components.

Maja Tarailo¹, Sanja Tarailo, Ann M Rose.

Abstract

Here, we report genetic interactions with mdf-1(gk2)/MAD1 in Caenorhabditis elegans. Nine are evolutionarily conserved or phenotypic "interologs" and two are novel enhancers, hcp-1 and bub-3. We show that HCP-1 and HCP-2, the two CENP-F-related proteins, recently implicated in the spindle assembly checkpoint (SAC) function, do not have identical functions, since hcp-1(RNAi), but not hcp-2(RNAi), enhances the lethality of the SAC mutants.

Entities: Gene Species

Mesh：

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Year: 2007 PMID： 18073444 PMCID： PMC2219473 DOI： 10.1534/genetics.107.080408

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

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