B H L Tan1, D A C Deans, R J E Skipworth, J A Ross, K C H Fearon. 1. Clinical and Surgical Sciences (Surgery), School of Clinical Sciences and Community Health, The University of Edinburgh, Royal Infirmary, Edinburgh, UK. benjamin.tan@ed.ac.uk
Abstract
INTRODUCTION: Cancer cachexia is a severe debilitating disorder, which causes significant morbidity and mortality. In clinical practice, cachexia is often not treated until a late stage, when therapeutic options are limited. OBJECTIVE: It is therefore of great interest to analyse early biomarkers of this syndrome. CONCLUSION: In this review article, we summarise recent biomarkers found in various body compartments. We also explore the likelihood of a genetic predisposition to cachexia and focus on the potential role of single nucleotide polymorphisms in genes coding for pro- and anti-inflammatory cytokines, and 'atrogenes' associated with wasting in skeletal muscle.
INTRODUCTION:Cancer cachexia is a severe debilitating disorder, which causes significant morbidity and mortality. In clinical practice, cachexia is often not treated until a late stage, when therapeutic options are limited. OBJECTIVE: It is therefore of great interest to analyse early biomarkers of this syndrome. CONCLUSION: In this review article, we summarise recent biomarkers found in various body compartments. We also explore the likelihood of a genetic predisposition to cachexia and focus on the potential role of single nucleotide polymorphisms in genes coding for pro- and anti-inflammatory cytokines, and 'atrogenes' associated with wasting in skeletal muscle.
Authors: D Attaix; E Aurousseau; L Combaret; A Kee; D Larbaud; C Rallière; B Souweine; D Taillandier; T Tilignac Journal: Reprod Nutr Dev Date: 1998 Mar-Apr
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