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Literature DB >> 18070148

Translational mini-review series on complement factor H: therapies of renal diseases associated with complement factor H abnormalities: atypical haemolytic uraemic syndrome and membranoproliferative glomerulonephritis.

Abstract

Genetic and acquired abnormalities in complement factor H (CFH) have been associated with two different human renal diseases: haemolytic uraemic syndrome and membrano proliferative glomerulonephritis. The new genetic and pathogenetic findings in these diseases and their clinical implications for the management and cure of patients are reviewed in this paper.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2007 PMID： 18070148 PMCID： PMC2276938 DOI： 10.1111/j.1365-2249.2007.03558.x

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

98 in total

1. Severity of primary MPGN, rather than MPGN type, determines renal survival and post-transplantation recurrence risk.

Authors: M A Little; P Dupont; E Campbell; A Dorman; J J Walshe
Journal: Kidney Int Date: 2006-02 Impact factor: 10.612

2. Complement factor H-associated atypical hemolytic uremic syndrome in monozygotic twins: concordant presentation, discordant response to treatment.

Authors: Jean-Claude Davin; Karolien H Olie; René Verlaak; Flore Horuz; Sandrine Florquin; Jan J Weening; Jaap W Groothoff; Lisa Strain; Timothy H J Goodship
Journal: Am J Kidney Dis Date: 2006-02 Impact factor: 8.860

3. Angiotensin blockade in children with chronic glomerulonephritis and heavy proteinuria.

Authors: Lavjay Butani
Journal: Pediatr Nephrol Date: 2005-08-16 Impact factor: 3.714

4. Efficiency of curative and prophylactic treatment with rituximab in ADAMTS13-deficient thrombotic thrombocytopenic purpura: a study of 11 cases.

Authors: Fadi Fakhouri; Jean-Paul Vernant; Agnès Veyradier; Martine Wolf; Gilles Kaplanski; Raynald Binaut; Manfred Rieger; Friedrich Scheiflinger; Pascale Poullin; Benjamin Deroure; Richard Delarue; Philippe Lesavre; Philippe Vanhille; Olivier Hermine; Giuseppe Remuzzi; Jean-Pierre Grünfeld
Journal: Blood Date: 2005-06-02 Impact factor: 22.113

5. Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice.

Authors: M C Pickering; J Warren; K L Rose; F Carlucci; Y Wang; M J Walport; H T Cook; M Botto
Journal: Proc Natl Acad Sci U S A Date: 2006-06-12 Impact factor: 11.205

6. Insights into hemolytic uremic syndrome: segregation of three independent predisposition factors in a large, multiple affected pedigree.

Authors: Jorge Esparza-Gordillo; Elena Goicoechea de Jorge; Cynthia Abarrategui Garrido; Luis Carreras; Margarita López-Trascasa; Pilar Sánchez-Corral; Santiago Rodríguez de Córdoba
Journal: Mol Immunol Date: 2006-01-18 Impact factor: 4.407

7. Heterozygous and homozygous factor h deficiencies associated with hemolytic uremic syndrome or membranoproliferative glomerulonephritis: report and genetic analysis of 16 cases.

Authors: Marie-Agnès Dragon-Durey; Véronique Frémeaux-Bacchi; Chantal Loirat; Jacques Blouin; Patrick Niaudet; Georges Deschenes; Paul Coppo; Wolf Herman Fridman; Laurence Weiss
Journal: J Am Soc Nephrol Date: 2004-03 Impact factor: 10.121

8. Clinico-pathological findings in diarrhoea-negative haemolytic uraemic syndrome.

Authors: C M Taylor; C Chua; A J Howie; R A Risdon
Journal: Pediatr Nephrol Date: 2004-02-24 Impact factor: 3.714

9. Complement factor H mutations and gene polymorphisms in haemolytic uraemic syndrome: the C-257T, the A2089G and the G2881T polymorphisms are strongly associated with the disease.

Authors: Jessica Caprioli; Federica Castelletti; Sara Bucchioni; Paola Bettinaglio; Elena Bresin; Gaia Pianetti; Sara Gamba; Simona Brioschi; Erica Daina; Giuseppe Remuzzi; Marina Noris
Journal: Hum Mol Genet Date: 2003-10-28 Impact factor: 6.150

Translational mini-review series on complement factor H: therapies of renal diseases associated with complement factor H abnormalities: atypical haemolytic uraemic syndrome and membranoproliferative glomerulonephritis.

1. Severity of primary MPGN, rather than MPGN type, determines renal survival and post-transplantation recurrence risk.

2. Complement factor H-associated atypical hemolytic uremic syndrome in monozygotic twins: concordant presentation, discordant response to treatment.

3. Angiotensin blockade in children with chronic glomerulonephritis and heavy proteinuria.

4. Efficiency of curative and prophylactic treatment with rituximab in ADAMTS13-deficient thrombotic thrombocytopenic purpura: a study of 11 cases.

5. Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice.

6. Insights into hemolytic uremic syndrome: segregation of three independent predisposition factors in a large, multiple affected pedigree.

7. Heterozygous and homozygous factor h deficiencies associated with hemolytic uremic syndrome or membranoproliferative glomerulonephritis: report and genetic analysis of 16 cases.

8. Clinico-pathological findings in diarrhoea-negative haemolytic uraemic syndrome.

9. Complement factor H mutations and gene polymorphisms in haemolytic uraemic syndrome: the C-257T, the A2089G and the G2881T polymorphisms are strongly associated with the disease.

10. Familial haemolytic uraemic syndrome and an MCP mutation.

Review 1. Review: Complement and its regulatory proteins in kidney diseases.

Review 2. Clinical practice. Today's understanding of the haemolytic uraemic syndrome.

3. Complement inhibitor eculizumab in atypical hemolytic uremic syndrome.

4. Structure of complement fragment C3b-factor H and implications for host protection by complement regulators.

5. Quantification of Factor H Mediated Self vs. Non-self Discrimination by Mathematical Modeling.

Review 6. Complement and the atypical hemolytic uremic syndrome in children.