Literature DB >> 18068894

NS5ATP9, a gene up-regulated by HCV NS5A protein.

Lei Shi1, Shu-Lin Zhang, Kang Li, Yuan Hong, Qi Wang, Yue Li, Jiang Guo, Wan-hu Fan, Lei Zhang, Jun Cheng.   

Abstract

Non-structural protein 5A (NS5A) appears to interact with a variety of cellular proteins and play an important role in mediating cell growth, cellular signaling pathways and pathogenesis of hepatitis C virus (HCV). NS5ATP9 was identified as a NS5A trans-activated protein in suppression subtractive hybridization (SSH), and the regulation was confirmed by luciferase reporter assay and quantitative real time PCR (qRT-PCR). A minimal promoter region contained within the 211bp (nucleotides -161 to +50bp) immediately upstream of the transcription initiation site. NS5ATP9 is a NS5A up-regulation gene which may play a role in the pathogenesis of HCV-associated hepatocellular carcinoma.

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Year:  2008        PMID： 18068894     DOI： 10.1016/j.canlet.2007.10.029

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  10 in total

Review 1.  Hepatitis viruses and non-Hodgkin's lymphoma: A review.

Authors:  Sibnarayan Datta; Soumya Chatterjee; Rudragoud S Policegoudra; Hemant K Gogoi; Lokendra Singh
Journal:  World J Virol       Date:  2012-12-12

2.  Monitoring coagulation proteins during progression of liver disease.

Authors:  Mohamed Hessien; Mohamed Ayad; Wafaa M Ibrahim; Batoul Izz ulArab
Journal:  Indian J Clin Biochem       Date:  2014-04-19

3.  TAF and TDF attenuate liver fibrosis through NS5ATP9, TGFβ1/Smad3, and NF-κB/NLRP3 inflammasome signaling pathways.

Authors:  Jing Zhao; Ming Han; Li Zhou; Pu Liang; Yun Wang; Shenghu Feng; Hongping Lu; Xiaoxue Yuan; Kai Han; Xiaofan Chen; Shunai Liu; Jun Cheng
Journal:  Hepatol Int       Date:  2019-11-22       Impact factor: 6.047

4.  NS5ATP9 suppresses activation of human hepatic stellate cells, possibly via inhibition of Smad3/phosphorylated-Smad3 expression.

Authors:  Mengran Zhang; Jinqian Zhang; Shunai Liu; Qi Wang; Guoxian Lin; Rongxian Qiu; Min Quan; Jun Cheng
Journal:  Inflammation       Date:  2015-02       Impact factor: 4.092

5.  Tenofovir alafenamide fumarate attenuates bleomycin-induced pulmonary fibrosis by upregulating the NS5ATP9 and TGF-β1/Smad3 signaling pathway.

Authors:  Lingxia Li; Jing Zhao; Li Zhou; Jie Chen; Yuanyuan Ma; Yanyan Yu; Jun Cheng
Journal:  Respir Res       Date:  2019-07-22

6.  Regulation of hepatitis C virus replication by nuclear translocation of nonstructural 5A protein and transcriptional activation of host genes.

Authors:  Muhammad Ahmad Maqbool; Mohamed R Imache; Martin R Higgs; Sophie Carmouse; Jean-Michel Pawlotsky; Hervé Lerat
Journal:  J Virol       Date:  2013-03-06       Impact factor: 5.103

7.  NS5ATP9 contributes to inhibition of cell proliferation by hepatitis C virus (HCV) nonstructural protein 5A (NS5A) via MEK/extracellular signal regulated kinase (ERK) pathway.

Authors:  Qi Wang; Yongsheng Wang; Yue Li; Xuesong Gao; Shunai Liu; Jun Cheng
Journal:  Int J Mol Sci       Date:  2013-05-21       Impact factor: 5.923

8.  Identification and functional analysis of a core gene module associated with hepatitis C virus-induced human hepatocellular carcinoma progression.

Authors:  Gaobo Bai; Wenling Zheng; Wenli Ma
Journal:  Oncol Lett       Date:  2018-03-09       Impact factor: 2.967

9.  Prognostic value and underlying mechanism of KIAA0101 in hepatocellular carcinoma: database mining and co-expression analysis.

Authors:  Weiyu Xu; Xuezhu Wang; Xiaoqian Wu; Si Yu; Jianping Xiong; Xinting Sang; Yongchang Zheng; Zhongtao Zhang
Journal:  Aging (Albany NY)       Date:  2020-08-27       Impact factor: 5.682

10.  Increased KIAA0101 gene expression associated with poor prognosis in breast cancer.

Authors:  Jiuyang Liu; Yukun He; Chengxin Li; Rui Zhou; Qianqian Yuan; Jinxuan Hou; Gaosong Wu
Journal:  Transl Cancer Res       Date:  2021-09       Impact factor: 1.241
  10 in total

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