| Literature DB >> 18068363 |
Roland L Knight1, Daniel R Allen, Helen L Birch, Gayle A Chapman, Frances C Galvin, Louise A Jopling, Christopher J Lock, Johannes W G Meissner, David A Owen, Gilles Raphy, Robert J Watson, Sophie C Williams.
Abstract
The synthesis and biological evaluation of a novel series of 2-aminoquinoline substituted piperidines and tropanes incorporating a homotropene moiety is herein described. The series exhibits potent antagonism of the CXCR3 receptor and superior physicochemical properties. Compound 24d was found to be orally bioavailable, and PK/PD studies suggested it as a suitable tool for studying the role of CXCR3 in models of disease.Entities:
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Year: 2007 PMID： 18068363 DOI： 10.1016/j.bmcl.2007.11.075
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823