OBJECTIVE: To evaluate whether overweight and obesity are related to changes in serum sex hormone concentrations and semen quality. DESIGN: Cross-sectional study. SETTING: Data from five previous population-based environmental studies of semen quality were combined into one database at a university hospital in Denmark. PATIENT(S): In total, 2,139 men provided data to the database. INTERVENTION(S): Data on semen and blood samples and information on lifestyle and reproductive factors, including body mass index (BMI), were collected. MAIN OUTCOME MEASURE(S): Semen quality (volume, concentration, total sperm count, and motility) and serum concentration of sex hormones. RESULT(S): The T and inhibin B serum concentrations were 25%-32% lower in obese men in comparison with normal-weight men, whereas the E(2) concentration was 6% higher in obese men. Overweight men (BMI, 25.1-30.0 kg/m(2)) had a slightly lower adjusted sperm concentration and total sperm count than did men with a normal BMI (20.0-25.0 kg/m(2)), but no reduction in sperm count was observed among the obese men. CONCLUSION(S): These results corroborate earlier findings that overweight and obese men have a markedly changed sex hormone profile in serum, whereas reduction of semen quality, if any, was marginal and below the detection limit of this large study.
OBJECTIVE: To evaluate whether overweight and obesity are related to changes in serum sex hormone concentrations and semen quality. DESIGN: Cross-sectional study. SETTING: Data from five previous population-based environmental studies of semen quality were combined into one database at a university hospital in Denmark. PATIENT(S): In total, 2,139 men provided data to the database. INTERVENTION(S): Data on semen and blood samples and information on lifestyle and reproductive factors, including body mass index (BMI), were collected. MAIN OUTCOME MEASURE(S): Semen quality (volume, concentration, total sperm count, and motility) and serum concentration of sex hormones. RESULT(S): The T and inhibin B serum concentrations were 25%-32% lower in obesemen in comparison with normal-weight men, whereas the E(2) concentration was 6% higher in obesemen. Overweight men (BMI, 25.1-30.0 kg/m(2)) had a slightly lower adjusted sperm concentration and total sperm count than did men with a normal BMI (20.0-25.0 kg/m(2)), but no reduction in sperm count was observed among the obesemen. CONCLUSION(S): These results corroborate earlier findings that overweight and obesemen have a markedly changed sex hormone profile in serum, whereas reduction of semen quality, if any, was marginal and below the detection limit of this large study.
Authors: Linda G Kahn; Elizabeth M Widen; Teresa Janevic; Nadine Straka; Xinhua Liu; Piera M Cirillo; Barbara A Cohn; Germaine M Buck Louis; Pam Factor-Litvak Journal: Epidemiology Date: 2019-11 Impact factor: 4.822
Authors: Tod Fullston; Helana Shehadeh; Lauren Y Sandeman; Wan Xian Kang; Linda L Wu; Rebecca L Robker; Nicole O McPherson; Michelle Lane Journal: J Assist Reprod Genet Date: 2015-04-09 Impact factor: 3.412
Authors: Guilherme Jacom Abdulmassih Wood; Bruno C Tiseo; Davi V Paluello; Hamilton de Martin; Marco Aurelio Santo; William Nahas; Miguel Srougi; Marcello Cocuzza Journal: Obes Surg Date: 2020-07-22 Impact factor: 4.129
Authors: N Sermondade; C Faure; L Fezeu; A G Shayeb; J P Bonde; T K Jensen; M Van Wely; J Cao; A C Martini; M Eskandar; J E Chavarro; S Koloszar; J M Twigt; C H Ramlau-Hansen; E Borges; F Lotti; R P M Steegers-Theunissen; B Zorn; A J Polotsky; S La Vignera; B Eskenazi; K Tremellen; E V Magnusdottir; I Fejes; S Hercberg; R Lévy; S Czernichow Journal: Hum Reprod Update Date: 2012-12-12 Impact factor: 15.610