William G Christen1, Robert J Glynn, Emily Y Chew, Julie E Buring. 1. Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. wchristen@rics.bwh.harvard.edu
Abstract
OBJECTIVE: To investigate whether vitamin E supplementation decreases the risk of age-related cataract in women. DESIGN: Randomized, double-masked, placebo-controlled trial. PARTICIPANTS: Thirty-nine thousand eight hundred seventy-six apparently healthy female health professionals aged 45 years or older. INTERVENTION: Participants were assigned randomly to receive either 600 IU natural-source vitamin E on alternate days or placebo and were followed up for presence of cataract for an average of 9.7 years. MAIN OUTCOME MEASURE: Age-related cataract defined as an incident, age-related lens opacity, responsible for a reduction in best-corrected visual acuity to 20/30 or worse, based on self-report and confirmed by medical record review. RESULTS: There was no significant difference between the vitamin E and placebo groups in the incidence of cataract (1159 vs. 1217 cases; relative risk [RR], 0.96; 95% confidence interval [CI], 0.88-1.04). In subgroup analyses of subtypes, there were no significant effects of vitamin E on the incidence of nuclear (1056 vs. 1127 cases; RR, 0.94; 95% CI, 0.87-1.02), cortical (426 vs. 461 cases; RR, 0.93; 95% CI, 0.81-1.06), or posterior subcapsular cataract (357 vs. 359 cases; RR, 1.00; 95% CI, 0.86-1.16). Results were similar for extraction of cataract and subtypes. There was no modification of the lack of effect of vitamin E on cataract by baseline categories of age, cigarette smoking, multivitamin use, or several other possible risk factors for cataract. CONCLUSIONS: These data from a large trial of apparently healthy female health professionals with 9.7 years of treatment and follow-up indicate that 600 IU natural-source vitamin E taken every other day provides no benefit for age-related cataract or subtypes.
RCT Entities:
OBJECTIVE: To investigate whether vitamin E supplementation decreases the risk of age-related cataract in women. DESIGN: Randomized, double-masked, placebo-controlled trial. PARTICIPANTS: Thirty-nine thousand eight hundred seventy-six apparently healthy female health professionals aged 45 years or older. INTERVENTION: Participants were assigned randomly to receive either 600 IU natural-source vitamin E on alternate days or placebo and were followed up for presence of cataract for an average of 9.7 years. MAIN OUTCOME MEASURE: Age-related cataract defined as an incident, age-related lens opacity, responsible for a reduction in best-corrected visual acuity to 20/30 or worse, based on self-report and confirmed by medical record review. RESULTS: There was no significant difference between the vitamin E and placebo groups in the incidence of cataract (1159 vs. 1217 cases; relative risk [RR], 0.96; 95% confidence interval [CI], 0.88-1.04). In subgroup analyses of subtypes, there were no significant effects of vitamin E on the incidence of nuclear (1056 vs. 1127 cases; RR, 0.94; 95% CI, 0.87-1.02), cortical (426 vs. 461 cases; RR, 0.93; 95% CI, 0.81-1.06), or posterior subcapsular cataract (357 vs. 359 cases; RR, 1.00; 95% CI, 0.86-1.16). Results were similar for extraction of cataract and subtypes. There was no modification of the lack of effect of vitamin E on cataract by baseline categories of age, cigarette smoking, multivitamin use, or several other possible risk factors for cataract. CONCLUSIONS: These data from a large trial of apparently healthy female health professionals with 9.7 years of treatment and follow-up indicate that 600 IU natural-source vitamin E taken every other day provides no benefit for age-related cataract or subtypes.
Authors: William G Christen; Robert J Glynn; Emily Y Chew; Christine M Albert; JoAnn E Manson Journal: Ophthalmic Epidemiol Date: 2016-01-20 Impact factor: 1.648
Authors: William G Christen; Robert J Glynn; J Michael Gaziano; Amy K Darke; John J Crowley; Phyllis J Goodman; Scott M Lippman; Thomas E Lad; James D Bearden; Gary E Goodman; Lori M Minasian; Ian M Thompson; Charles D Blanke; Eric A Klein Journal: JAMA Ophthalmol Date: 2015-01 Impact factor: 7.389
Authors: William G Christen; Robert J Glynn; Howard D Sesso; Tobias Kurth; Jean MacFadyen; Vadim Bubes; Julie E Buring; JoAnn E Manson; J Michael Gaziano Journal: Arch Ophthalmol Date: 2010-11
Authors: William G Christen; Robert J Glynn; Joann E Manson; Jean MacFadyen; Vadim Bubes; Miriam Schvartz; Julie E Buring; Howard D Sesso; J Michael Gaziano Journal: Ophthalmology Date: 2013-11-20 Impact factor: 12.079