Literature DB >> 18067556

Regulatory T cells and tumour immunity - observations in mice and men.

Awen Gallimore1, Andrew Godkin.   

Abstract

An enormous body of work supports a role for CD4+ CD25+ regulatory cells (Tregs) in shaping the immune response to tumours. Indeed, there is evidence that the cells impede effective tumour immunosurveillance, inhibit vaccine-induced antitumour immune responses and promote tumour progression. Studies exploring the impact of Tregs on tumour development are discussed in the context of manipulating this T-cell population for the purpose of cancer immunotherapy.

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Year:  2007        PMID： 18067556      PMCID： PMC2433304          DOI： 10.1111/j.1365-2567.2007.02748.x

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  41 in total

Review 1.  Cancer immunoediting: from immunosurveillance to tumor escape.

Authors:  Gavin P Dunn; Allen T Bruce; Hiroaki Ikeda; Lloyd J Old; Robert D Schreiber
Journal:  Nat Immunol       Date:  2002-11       Impact factor: 25.606

2.  Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance.

Authors:  Jun Shimizu; Sayuri Yamazaki; Takeshi Takahashi; Yasumasa Ishida; Shimon Sakaguchi
Journal:  Nat Immunol       Date:  2002-01-22       Impact factor: 25.606

3.  Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo.

Authors:  Mei-Ling Chen; Mikaël J Pittet; Leonid Gorelik; Richard A Flavell; Ralph Weissleder; Harald von Boehmer; Khashayarsha Khazaie
Journal:  Proc Natl Acad Sci U S A       Date:  2004-12-27       Impact factor: 11.205

4.  CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer.

Authors:  Y Naito; K Saito; K Shiiba; A Ohuchi; K Saigenji; H Nagura; H Ohtani
Journal:  Cancer Res       Date:  1998-08-15       Impact factor: 12.701

5.  Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.

Authors:  Tyler J Curiel; George Coukos; Linhua Zou; Xavier Alvarez; Pui Cheng; Peter Mottram; Melina Evdemon-Hogan; Jose R Conejo-Garcia; Lin Zhang; Matthew Burow; Yun Zhu; Shuang Wei; Ilona Kryczek; Ben Daniel; Alan Gordon; Leann Myers; Andrew Lackner; Mary L Disis; Keith L Knutson; Lieping Chen; Weiping Zou
Journal:  Nat Med       Date:  2004-08-22       Impact factor: 53.440

6.  Survival and the immune response in patients with carcinoma of the colorectum.

Authors:  A K House; A G Watt
Journal:  Gut       Date:  1979-10       Impact factor: 23.059

7.  Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells.

Authors:  Fumiko Kanamaru; Pornpan Youngnak; Masaaki Hashiguchi; Tomohisa Nishioka; Takeshi Takahashi; Shimon Sakaguchi; Isao Ishikawa; Miyuki Azuma
Journal:  J Immunol       Date:  2004-06-15       Impact factor: 5.422

8.  Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer.

Authors:  Lin Zhang; Jose R Conejo-Garcia; Dionyssios Katsaros; Phyllis A Gimotty; Marco Massobrio; Giorgia Regnani; Antonis Makrigiannakis; Heidi Gray; Katia Schlienger; Michael N Liebman; Stephen C Rubin; George Coukos
Journal:  N Engl J Med       Date:  2003-01-16       Impact factor: 91.245

9.  Immunologically mediated regression of a murine lymphoma after treatment with anti-L3T4 antibody. A consequence of removing L3T4+ suppressor T cells from a host generating predominantly Lyt-2+ T cell-mediated immunity.

Authors:  M Awwad; R J North
Journal:  J Exp Med       Date:  1988-12-01       Impact factor: 14.307

10.  Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells.

Authors:  R J North
Journal:  J Exp Med       Date:  1982-04-01       Impact factor: 14.307
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  44 in total

1.  Analysis of the immune system of multiple myeloma patients achieving long-term disease control by multidimensional flow cytometry.

Authors:  Roberto J Pessoa de Magalhães; María-Belén Vidriales; Bruno Paiva; Carlos Fernandez-Gimenez; Ramón García-Sanz; Maria-Victoria Mateos; Norma C Gutierrez; Quentin Lecrevisse; Juan F Blanco; Jose Hernández; Natalia de las Heras; Joaquin Martinez-Lopez; Monica Roig; Elaine Sobral Costa; Enrique M Ocio; Martin Perez-Andres; Angelo Maiolino; Marcio Nucci; Javier De La Rubia; Juan-Jose Lahuerta; Jesús F San-Miguel; Alberto Orfao
Journal:  Haematologica       Date:  2012-07-06       Impact factor: 9.941

2.  Novel role of regulatory T cells in limiting early neutrophil responses in skin.

Authors:  Hannah Richards; Anwen Williams; Emma Jones; James Hindley; Andrew Godkin; Anna Katharina Simon; Awen Gallimore
Journal:  Immunology       Date:  2010-08-17       Impact factor: 7.397

3.  Suppression of murine colitis and its associated cancer by carcinoembryonic antigen-specific regulatory T cells.

Authors:  Dan Blat; Ehud Zigmond; Zoya Alteber; Tova Waks; Zelig Eshhar
Journal:  Mol Ther       Date:  2014-03-06       Impact factor: 11.454

4.  Enhanced antitumor effects and improved immune status of dendritic cell and cytokine-induced killer cell infusion in advanced cancer patients.

Authors:  Feng Chen; Menghan Yang; Qingkun Song; Jiangping Wu; Xiaoli Wang; Xinna Zhou; Yanhua Yuan; Yuguang Song; Ni Jiang; Yanjie Zhao; Lei Zhou; Jun Ren
Journal:  Mol Clin Oncol       Date:  2017-09-19

5.  T regulatory cell mediated immunotherapy for solid organ transplantation: A clinical perspective.

Authors:  Mohammad Afzal Khan
Journal:  Mol Med       Date:  2016-11-22       Impact factor: 6.354

6.  Discovery of small molecule inhibitors to Krüppel-like factor 10 (KLF10): implications for modulation of T regulatory cell differentiation.

Authors:  Santosh A Khedkar; Xinghui Sun; Alan C Rigby; Mark W Feinberg
Journal:  J Med Chem       Date:  2015-02-04       Impact factor: 7.446

7.  Immunological tolerance and tumor rejection in embryo-aggregated chimeric mice - lessons for tumor immunity.

Authors:  Alexander Y Wagner; Eric Holle; Lori Holle; Xianzhong Yu; Günter Schwamberger
Journal:  BMC Cancer       Date:  2008-12-16       Impact factor: 4.430

8.  OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis.

Authors:  Daniel Hirschhorn-Cymerman; Gabrielle A Rizzuto; Taha Merghoub; Adam D Cohen; Francesca Avogadri; Alexander M Lesokhin; Andrew D Weinberg; Jedd D Wolchok; Alan N Houghton
Journal:  J Exp Med       Date:  2009-05-04       Impact factor: 14.307

Review 9.  Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment?

Authors:  Leigh R Guerin; Jelmer R Prins; Sarah A Robertson
Journal:  Hum Reprod Update       Date:  2009-03-11       Impact factor: 15.610

10.  Different subsets of tumor infiltrating lymphocytes correlate with NPC progression in different ways.

Authors:  Yi-Lan Zhang; Jiang Li; Hao-Yuan Mo; Fang Qiu; Li-Min Zheng; Chao-Nan Qian; Yi-Xin Zeng
Journal:  Mol Cancer       Date:  2010-01-10       Impact factor: 27.401
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