Literature DB >> 18066886

Synthesis and antitumor activity of fluorocyclopentenyl-pyrimidines.

Lak Shin Jeong1, Long Xuan Zhao, Won Jun Choi, Shantanu Pal, Yeon Hee Park, Sang Kook Lee, Moon Woo Chun, Young B Lee, Chang Ho Ahn, Hyung Ryong Moon.   

Abstract

Synthesis of fluorocyclopentenyl pyrimidine nucleosides 6-9 was enantiopurely accomplished employing oxidative rearrangement, RCM reaction and electrophilic fluorination starting from d-ribose. Cytosine analog 8 was found to exhibit significant anticancer activity in various human tumor cell lines.

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Year:  2007        PMID: 18066886     DOI: 10.1080/15257770701490852

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN: 1525-7770            Impact factor:   1.381


  4 in total

1.  Incorporating DNA Methyltransferase Inhibitors (DNMTis) in the Treatment of Genitourinary Malignancies: A Systematic Review.

Authors:  Michal Chovanec; Fadi Taza; Maitri Kalra; Noah Hahn; Kenneth P Nephew; Michael J Spinella; Costantine Albany
Journal:  Target Oncol       Date:  2018-02       Impact factor: 4.493

Review 2.  Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues.

Authors:  Mieke Guinan; Caecilie Benckendorff; Mark Smith; Gavin J Miller
Journal:  Molecules       Date:  2020-04-28       Impact factor: 4.411

3.  Antioxidant Activity of Telmisartan-Cu(II) Nanoparticles Connected 2-Pyrimidinamine and Their Evaluation of Cytotoxicity Activities.

Authors:  Radhakrishnan Surendrakumar; Akbar Idhayadhulla; Saud Alarifi; Nazeer Anis Ahamed; Chidambaram Sathish Kumar
Journal:  Biomed Res Int       Date:  2020-11-18       Impact factor: 3.411

4.  In silico molecular docking and in vitro antidiabetic studies of dihydropyrimido[4,5-a]acridin-2-amines.

Authors:  A Bharathi; Selvaraj Mohana Roopan; C S Vasavi; Punnagai Munusami; G A Gayathri; M Gayathri
Journal:  Biomed Res Int       Date:  2014-06-02       Impact factor: 3.411

  4 in total

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