Literature DB >> 18066844

Attachment of cholesterol to amino-LNA: synthesis and hybridization properties.

Torsten Bryld1, Christian Lomholt.   

Abstract

Here, we present our synthesis of amino-LNA with a C6-linker and hybridization studies of these. A cholesterol moiety was attached at the end of the C6-linker. This resulted in drastic drops against DNA of the modified oligonucleotide.

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Year:  2007        PMID: 18066844     DOI: 10.1080/15257770701549095

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN: 1525-7770            Impact factor:   1.381


  1 in total

1.  Synthesis and biophysical properties of C5-functionalized LNA (locked nucleic acid).

Authors:  Pawan Kumar; Michael E Østergaard; Bharat Baral; Brooke A Anderson; Dale C Guenther; Mamta Kaura; Daniel J Raible; Pawan K Sharma; Patrick J Hrdlicka
Journal:  J Org Chem       Date:  2014-05-13       Impact factor: 4.354

  1 in total

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