Literature DB >> 18066840

2',4'-BNA(NC): a novel bridged nucleic acid analogue with excellent hybridizing and nuclease resistance profiles.

S M Abdur Rahman1, Sayori Seki, Kazushige Utsuki, Satoshi Obika, Kazuyuki Miyashita, Takeshi Imanishi.   

Abstract

Oligonucleotides modified with 2 ',4 '-BNA(NC) (N-H)/(N-Me) monomers exhibited excellent hybridizing and nuclease resistance properties. Duplex and triplex thermal stabilities were greatly enhanced by incorporating 2',4'-BNA(NC) (N-H) and (N-Me) monomers and nuclease resistance was tremendously higher than that of natural oligonucleotide.

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Year:  2007        PMID： 18066840     DOI： 10.1080/15257770701548980

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN： 1525-7770            Impact factor:   1.381


  5 in total

1.  Inhibition of AAC(6')-Ib-mediated resistance to amikacin in Acinetobacter baumannii by an antisense peptide-conjugated 2',4'-bridged nucleic acid-NC-DNA hybrid oligomer.

Authors:  Christina Lopez; Brock A Arivett; Luis A Actis; Marcelo E Tolmasky
Journal:  Antimicrob Agents Chemother       Date:  2015-07-13       Impact factor: 5.191

2.  Synthesis of Sugar and Nucleoside Analogs and Evaluation of Their Anticancer and Analgesic Potentials.

Authors:  Fahad Hussain; Fahad Imtiaz Rahman; Poushali Saha; Atsushi Mikami; Takashi Osawa; Satoshi Obika; S M Abdur Rahman
Journal:  Molecules       Date:  2022-05-29       Impact factor: 4.927

3.  Assessment of configurations and chemistries of bridged nucleic acids-containing oligomers as external guide sequences: a methodology for inhibition of expression of antibiotic resistance genes.

Authors:  Alexis Jackson; Saumya Jani; Carol Davies Sala; Alfonso J C Soler-Bistué; Angeles Zorreguieta; Marcelo E Tolmasky
Journal:  Biol Methods Protoc       Date:  2016-03-01

4.  Using high-sensitivity sequencing for the detection of mutations in BTK and PLCγ2 genes in cellular and cell-free DNA and correlation with progression in patients treated with BTK inhibitors.

Authors:  Adam Albitar; Wanlong Ma; Ivan DeDios; Jeffrey Estella; Inhye Ahn; Mohammed Farooqui; Adrian Wiestner; Maher Albitar
Journal:  Oncotarget       Date:  2017-03-14

5.  A bridged nucleic acid, 2',4'-BNA COC: synthesis of fully modified oligonucleotides bearing thymine, 5-methylcytosine, adenine and guanine 2',4'-BNA COC monomers and RNA-selective nucleic-acid recognition.

Authors:  Yasunori Mitsuoka; Tetsuya Kodama; Ryo Ohnishi; Yoshiyuki Hari; Takeshi Imanishi; Satoshi Obika
Journal:  Nucleic Acids Res       Date:  2009-01-09       Impact factor: 16.971
  5 in total

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