| Literature DB >> 18066816 |
Sergey N Mikhailov1, Georgii V Bobkov, Kyrill V Brilliantov, Jef Rozenski, Arthur Van Aerschot, Piet Herdewijn, Michael H Fisher, Rudolph L Juliano.
Abstract
A simple and efficient method for the preparation of pyrimidine 2'-O-hydroxyethoxymethylribonucleosides and 2'-O-hydroxypropoxymethylribonucleosides has been developed. These modified nucleosides were incorporated into oligoribonucleotides, which were shown to form stable RNA/RNA duplexes. The effect of 2' -O-modification in the antisense and sense strands of small interference RNA was evaluated in multi-drug resistant NIH 3T3 cells.Entities:
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Year: 2007 PMID： 18066816 PMCID： PMC2692904 DOI： 10.1080/15257770701543007
Source DB: PubMed Journal: Nucleosides Nucleotides Nucleic Acids ISSN： 1525-7770 Impact factor: 1.381