| Literature DB >> 18066789 |
Julie Broggi1, Nicolas Joubert, Vincent Aucagne, Sabine Berteina-Raboin, S Diez-Gonzalez, Steve Nolan, Dimitri Topalis, Dominique Deville-Bonne, Jan Balzarini, Johan Neyts, Graciela Andrei, Robert Snoeck, Luigi A Agrofoglio.
Abstract
Hitherto unknown 1,4-disubstituted-[1,2,3]-triazolo-4',4'-dihydroxymethyl-3'-deoxy carbanucleosides were synthesized based on a "click approach." Various alkynes were introduced on a key azido intermediate by the "click" 1,3-dipolar Huisgen cycloaddition. Their antiviral activities and cellular toxicities were evaluated on vaccinia virus. None of the synthesized compounds exhibited a significant antiviral activity.Entities:
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Year: 2007 PMID： 18066789 DOI： 10.1080/15257770701534139
Source DB: PubMed Journal: Nucleosides Nucleotides Nucleic Acids ISSN： 1525-7770 Impact factor: 1.381