Literature DB >> 18065958

The drug release profile from calcium-induced alginate gel beads coated with an alginate hydrolysate.

Yoshifumi Murata1, Daisaku Jinno, Dongchun Liu, Takshi Isobe, Kyouko Kofuji, Susumu Kawashima.   

Abstract

Calcium-induced alginate gel bead (Alg-Ca) coated with an alginate hydrolysate (Alg), e.g. the guluronic acid block (GB) was prepared and the model drug, hydrocortisone release profiles were investigated under simulated gastrointestinal conditions. Their molecular weights were one sixth or one tenth that of Alg and the diffraction patterns of the hydrolysates resembled that of Alg. The drug release rate from Alg-Ca coated with GB apparently lowered than that of Alg-Ca (coating-free) in the gastric juice (pH1.2). And the coating did not resist the disintegration of Alg-Ca in the intestinal juice (pH 6.8) and the gel erosion accelerated the drug release. On the other hand, for the coated Alg-Ca containing chitosan, the drug release showed zero-order kinetics without rapid erosion of Alg-Ca. The drug release rate from Alg-Ca was able to be controlled by the coating and modifying the composition of the gel matrix.

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Year:  2007        PMID： 18065958      PMCID： PMC6149178          DOI： 10.3390/12112559

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  11 in total

1.  Kluyveromyces lactis cells entrapped in Ca-alginate beads for the continuous production of a heterologous glucoamylase.

Authors:  Elisabetta de Alteriis; Giovanni Silvestro; Massimo Poletto; Vittorio Romano; Daniele Capitanio; Concetta Compagno; Palma Parascandola
Journal:  J Biotechnol       Date:  2004-04-08       Impact factor: 3.307

2.  Modified alginate matrices for the immobilization of bioactive agents.

Authors:  Canh Le-Tien; Mathieu Millette; Monique Lacroix; Mircea-Alexandru Mateescu
Journal:  Biotechnol Appl Biochem       Date:  2004-04       Impact factor: 2.431

3.  The release behavior of brilliant blue from calcium-alginate gel beads coated by chitosan: the preparation method effect.

Authors:  X Z Shu; K J Zhu
Journal:  Eur J Pharm Biopharm       Date:  2002-03       Impact factor: 5.571

4.  Ionically crosslinked alginate hydrogels as scaffolds for tissue engineering: part 1. Structure, gelation rate and mechanical properties.

Authors:  C K Kuo; P X Ma
Journal:  Biomaterials       Date:  2001-03       Impact factor: 12.479

5.  Properties of calcium-induced gel beads prepared with alginate and hydrolysates.

Authors:  Yoshifumi Murata; Daisaku Jinno; Kyouko Kofuji; Susumu Kawashima
Journal:  Chem Pharm Bull (Tokyo)       Date:  2004-05       Impact factor: 1.645

6.  [Tolerance of a new calcium-alginate-insert for controlled medication therapy of the eye].

Authors:  B Fuchs-Koelwel; C Koelwel; A Göpferich; B Gabler; E Wiegrebe; C P Lohmann
Journal:  Ophthalmologe       Date:  2004-05       Impact factor: 1.059

7.  Physical alginate hydrogels based on hydrophobic or dual hydrophobic/ionic interactions: bead formation, structure, and stability.

Authors:  M Rastello De Boisseson; M Leonard; P Hubert; P Marchal; A Stequert; C Castel; E Favre; E Dellacherie
Journal:  J Colloid Interface Sci       Date:  2004-05-01       Impact factor: 8.128

8.  Gelation conditions and transport properties of hollow calcium alginate capsules.

Authors:  Yi Chai; Le-He Mei; Guo-Liang Wu; Dong-Qiang Lin; Shan-Jing Yao
Journal:  Biotechnol Bioeng       Date:  2004-07-20       Impact factor: 4.530

9.  Drug release properties of a gel bead prepared with pectin and hydrolysate.

Authors:  Yoshifumi Murata; Michiko Miyashita; Kyouko Kofuji; Etsuko Miyamoto; Susumu Kawashima
Journal:  J Control Release       Date:  2004-02-20       Impact factor: 9.776

10.  Cross-linked alginate-gelatine beads: a new matrix for controlled release of pindolol.

Authors:  P Ferreira Almeida; A J Almeida
Journal:  J Control Release       Date:  2004-07-07       Impact factor: 9.776
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  11 in total

1.  Enhanced Antibacterial Activity of Dermaseptin through Its Immobilization on Alginate Nanoparticles-Effects of Menthol and Lactic Acid on Its Potentialization.

Authors:  Noura Hazime; Yanath Belguesmia; Alexandre Barras; Mohamed Amiche; Rabah Boukherroub; Djamel Drider
Journal:  Antibiotics (Basel)       Date:  2022-06-09

2.  Induction of apoptosis in HeLa cancer cells by an ultrasonic-mediated synthesis of curcumin-loaded chitosan-alginate-STPP nanoparticles.

Authors:  Fatemeh Ahmadi; Maryam Ghasemi-Kasman; Shahram Ghasemi; Maryam Gholamitabar Tabari; Roghayeh Pourbagher; Sohrab Kazemi; Ali Alinejad-Mir
Journal:  Int J Nanomedicine       Date:  2017-11-29

3.  Preparation and evaluation of berberine alginate beads for stomach-specific delivery.

Authors:  Zhen-Hai Zhang; Yong-Shun Sun; Hui Pang; Were L L Munyendo; Hui-Xia Lv; Sheng-Liang Zhu
Journal:  Molecules       Date:  2011-12-14       Impact factor: 4.411

4.  The Influence of Chitosan Cross-linking on the Properties of Alginate Microparticles with Metformin Hydrochloride-In Vitro and In Vivo Evaluation.

Authors:  Marta Szekalska; Katarzyna Sosnowska; Agnieszka Zakrzeska; Irena Kasacka; Alicja Lewandowska; Katarzyna Winnicka
Journal:  Molecules       Date:  2017-01-22       Impact factor: 4.411

5.  Modular injectable matrices based on alginate solution/microsphere mixtures that gel in situ and co-deliver immunomodulatory factors.

Authors:  Yuki Hori; Amy M Winans; Darrell J Irvine
Journal:  Acta Biomater       Date:  2008-12-10       Impact factor: 8.947

6.  Chitosan-alginate nanoparticles as a novel drug delivery system for nifedipine.

Authors:  Ping Li; Ya-Ni Dai; Jun-Ping Zhang; Ai-Qin Wang; Qin Wei
Journal:  Int J Biomed Sci       Date:  2008-09

7.  Designing polymeric microparticulate drug delivery system for hydrophobic drug quercetin.

Authors:  Moumita Hazra; Dalia Dasgupta Mandal; Tamal Mandal; Saikat Bhuniya; Mallika Ghosh
Journal:  Saudi Pharm J       Date:  2015-01-10       Impact factor: 4.330

8.  Novel Method for Loading Microporous Ceramics Bone Grafts by Using a Directional Flow.

Authors:  Michael Seidenstuecker; Steffen Kissling; Juergen Ruehe; Norbert P Suedkamp; Hermann O Mayr; Anke Bernstein
Journal:  J Funct Biomater       Date:  2015-12-21

9.  Calcium Chloride Modified Alginate Microparticles Formulated by the Spray Drying Process: A Strategy to Prolong the Release of Freely Soluble Drugs.

Authors:  Marta Szekalska; Katarzyna Sosnowska; Anna Czajkowska-Kośnik; Katarzyna Winnicka
Journal:  Materials (Basel)       Date:  2018-08-24       Impact factor: 3.623

10.  Properties of an oral preparation containing a chitosan salt.

Authors:  Yoshifumi Murata; Youko Kodama; Daijirou Hirai; Kyouko Kofuji; Susumu Kawashima
Journal:  Molecules       Date:  2009-02-13       Impact factor: 4.411
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