Literature DB >> 18065428

ConoServer, a database for conopeptide sequences and structures.

Quentin Kaas1, Jan-C Westermann, Reena Halai, Conan K L Wang, David J Craik.   

Abstract

SUMMARY: ConoServer is a new database dedicated to conopeptides, a large family of peptides found in the venom of marine snails of the genus Conus. These peptides have an exceptional diversity of sequences and chemical modifications and their ability to block ion channels makes them important as drug leads and tools for physiological studies. ConoServer uses standardized names and a genetic and structural classification scheme to present data retrieved from SwissProt, GenBank, the Protein DataBank and the literature. The ConoServer web site incorporates specialized features like the graphic display of post-translational modifications that are extensively present in conopeptides. Currently, ConoServer manages 1214 nucleic sequences (from 54 Conus species), 2258 proteic sequences (from 66 Conus species) and 99 3D structures. AVAILABILITY: http://research1t.imb.uq.edu.au/conoserver/.

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Year:  2007        PMID: 18065428     DOI: 10.1093/bioinformatics/btm596

Source DB:  PubMed          Journal:  Bioinformatics        ISSN: 1367-4803            Impact factor:   6.937


  79 in total

1.  A helical conotoxin from Conus imperialis has a novel cysteine framework and defines a new superfamily.

Authors:  Mingyu Ye; Keith K Khoo; Shaoqiong Xu; Mi Zhou; Nonlawat Boonyalai; Matthew A Perugini; Xiaoxia Shao; Chengwu Chi; Charles A Galea; Chunguang Wang; Raymond S Norton
Journal:  J Biol Chem       Date:  2012-03-07       Impact factor: 5.157

2.  Proteomic analysis provides insights on venom processing in Conus textile.

Authors:  Lemmuel L Tayo; Bingwen Lu; Lourdes J Cruz; John R Yates
Journal:  J Proteome Res       Date:  2010-05-07       Impact factor: 4.466

3.  Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity.

Authors:  Ai-hua Jin; Sébastien Dutertre; Quentin Kaas; Vincent Lavergne; Petra Kubala; Richard J Lewis; Paul F Alewood
Journal:  Mol Cell Proteomics       Date:  2013-09-16       Impact factor: 5.911

Review 4.  Use of venom peptides to probe ion channel structure and function.

Authors:  Sébastien Dutertre; Richard J Lewis
Journal:  J Biol Chem       Date:  2010-02-26       Impact factor: 5.157

5.  Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist.

Authors:  Sulan Luo; Dongting Zhangsun; Peta J Harvey; Quentin Kaas; Yong Wu; Xiaopeng Zhu; Yuanyan Hu; Xiaodan Li; Victor I Tsetlin; Sean Christensen; Haylie K Romero; Melissa McIntyre; Cheryl Dowell; James C Baxter; Keith S Elmslie; David J Craik; J Michael McIntosh
Journal:  Proc Natl Acad Sci U S A       Date:  2015-07-13       Impact factor: 11.205

Review 6.  Integrating the discovery pipeline for novel compounds targeting ion channels.

Authors:  Grzegorz Bulaj
Journal:  Curr Opin Chem Biol       Date:  2008-08-03       Impact factor: 8.822

7.  ArachnoServer: a database of protein toxins from spiders.

Authors:  David L A Wood; Tomas Miljenović; Shuzhi Cai; Robert J Raven; Quentin Kaas; Pierre Escoubas; Volker Herzig; David Wilson; Glenn F King
Journal:  BMC Genomics       Date:  2009-08-13       Impact factor: 3.969

8.  Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom.

Authors:  Sébastien Dutertre; Ai-hua Jin; Quentin Kaas; Alun Jones; Paul F Alewood; Richard J Lewis
Journal:  Mol Cell Proteomics       Date:  2012-11-14       Impact factor: 5.911

9.  A novel arrangement of Cys residues in a paralytic peptide of Conus cancellatus (jr. syn.: Conus austini), a worm-hunting snail from the Gulf of Mexico.

Authors:  Manuel B Aguilar; Alejandro Zugasti-Cruz; Andrés Falcón; César V F Batista; Baldomero M Olivera; Edgar P Heimer de la Cotera
Journal:  Peptides       Date:  2013-03-07       Impact factor: 3.750

10.  Rapid sensitive analysis of cysteine rich peptide venom components.

Authors:  Beatrix M Ueberheide; David Fenyö; Paul F Alewood; Brian T Chait
Journal:  Proc Natl Acad Sci U S A       Date:  2009-04-20       Impact factor: 11.205

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