Literature DB >> 18064069

How to improve the survival of the fetal ventral mesencephalic cell transplanted in Parkinson's disease?

Jia Liu1, Hong-Yun Huang.   

Abstract

It has been extensively confirmed that fetal ventral mesencephalic cell (VMC) transplantation can ameliorate the symptoms of Parkinson's disease (PD). But there are still several problems to be resolved before the extensive clinical application of this technology. The major limitations are the poor survival of grafted dopamine (DA) neurons and restricted dopaminergic reinnervation of host striatum. Some attempts have been made to solve these problems including use of some trophic factor and co-transplantation with neural/paraneural origins. The purpose of this review is to overview advances of the means improving the survival of grafts and their current limitations.

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Year:  2007        PMID： 18064069      PMCID： PMC5550653          DOI： 10.1007/s12264-007-0056-4

Source DB:  PubMed          Journal:  Neurosci Bull        ISSN： 1995-8218            Impact factor:   5.203


  54 in total

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Authors:  Kursad Genc
Journal:  Med Hypotheses       Date:  2007-06-05       Impact factor: 1.538

Review 2.  Cell therapy in Parkinson's disease.

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Journal:  NeuroRx       Date:  2004-10

3.  Effects of intranigral vs intrastriatal fetal mesencephalic neural grafts on motor behavior disorders in a rat Parkinson model.

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Journal:  Surg Neurol       Date:  2005

Review 4.  Dopaminergic cells of the carotid body: physiological significance and possible therapeutic applications in Parkinson's disease.

Authors:  Juan José Toledo-Aral; Simón Méndez-Ferrer; Ricardo Pardal; José López-Barneo
Journal:  Brain Res Bull       Date:  2002-04       Impact factor: 4.077

Review 5.  The changing scene of neurotrophic factors.

Authors:  H Thoenen
Journal:  Trends Neurosci       Date:  1991-05       Impact factor: 13.837

6.  Restorative potential of dopaminergic grafts in presence of antioxidants in rat model of Parkinson's disease.

Authors:  A K Agrawal; R K Chaturvedi; S Shukla; K Seth; S Chauhan; A Ahmad; P K Seth
Journal:  J Chem Neuroanat       Date:  2004-12       Impact factor: 3.052

7.  Effect of glial cell line-derived neurotrophic factor (GDNF) co-transplantation with fetal ventral mesencephalic cells (VMC) on functional restoration in 6-hydroxydopamine (6-OHDA) lesioned rat model of Parkinson's disease: neurobehavioral, neurochemical and immunohistochemical studies.

Authors:  R K Chaturvedi; A K Agrawal; K Seth; S Shukla; S Chauhan; Y Shukla; C Sinha; P K Seth
Journal:  Int J Dev Neurosci       Date:  2003-11       Impact factor: 2.457

8.  Enhanced survival, reinnervation, and functional recovery of intrastriatal dopamine grafts co-transplanted with Schwann cells overexpressing high molecular weight FGF-2 isoforms.

Authors:  Marco Timmer; Frauke Müller-Ostermeyer; Verena Kloth; Christian Winkler; Claudia Grothe; Guido Nikkhah
Journal:  Exp Neurol       Date:  2004-05       Impact factor: 5.330

9.  Co-transplantation of carotid body and ventral mesencephalic cells as an alternative approach towards functional restoration in 6-hydroxydopamine-lesioned rats: implications for Parkinson's disease.

Authors:  S Shukla; A K Agrawal; R K Chaturvedi; K Seth; N Srivastava; C Sinha; Y Shukla; V K Khanna; P K Seth
Journal:  J Neurochem       Date:  2004-10       Impact factor: 5.372

10.  Alloimmunisation to donor antigens and immune rejection following foetal neural grafts to the brain in patients with Huntington's disease.

Authors:  Pierre Krystkowiak; Véronique Gaura; Myriam Labalette; Amandine Rialland; Philippe Remy; Marc Peschanski; Anne-Catherine Bachoud-Lévi
Journal:  PLoS One       Date:  2007-01-24       Impact factor: 3.240
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  3 in total

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2.  [Effect of the local application of stem cells on repairing facial nerve defects: a systematic review].

Authors:  Dan Zhao; Yue-Heng Li; Zheng-Yan Yang; Ting Cai; Xiao-Yan Wu; Yu Xia; Zhi Zhou
Journal:  Hua Xi Kou Qiang Yi Xue Za Zhi       Date:  2020-02-01

3.  In vitro maturation of dopaminergic neurons derived from mouse embryonic stem cells: implications for transplantation.

Authors:  Bradley Watmuff; Colin W Pouton; John M Haynes
Journal:  PLoS One       Date:  2012-02-22       Impact factor: 3.240
  3 in total

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