Chao Deng1, Mei Han, Xu-Feng Huang. 1. School of Health Sciences, University of Wollongong, Wollongong, NSW 2522, Australia. chao@uow.edu.au
Abstract
OBJECTIVE: In recent years, abnormal changes in the endocannabinoid system have been found in schizophrenia. The superior temporal gyrus (STG) is strongly implicated in the pathophysiology of schizophrenia, particularly with regards to auditory hallucinations. In this study, we investigated the binding density of cannabinoid CB1 receptors in the STG of schizophrenia patients compared to control subjects. METHODS: Quantitative autoradiography was used to investigate the binding densities of [(3)H]SR141716A (a selective antagonist) and [(3)H]CP-55940 (an agonist) to the CB1 receptors in the STG. Post-mortem brain tissue was obtained from the NSW Tissue Resource Centre (Australia). RESULTS: Contrasting to previous findings in the alterations of CB1 receptor densities in the prefrontal, anterior and posterior cingulate cortex of schizophrenia, which were suggested to be associated to impairment of cognition function, no significant difference was found between the schizophrenia and control cases in both [(3)H]SR141716A and [(3)H]CP-55940 binding. CONCLUSION: We suggest that CB1 receptors in the STG are not involved in the pathology of schizophrenia and the auditory hallucination symptom of this disease.
OBJECTIVE: In recent years, abnormal changes in the endocannabinoid system have been found in schizophrenia. The superior temporal gyrus (STG) is strongly implicated in the pathophysiology of schizophrenia, particularly with regards to auditory hallucinations. In this study, we investigated the binding density of cannabinoid CB1 receptors in the STG of schizophreniapatients compared to control subjects. METHODS: Quantitative autoradiography was used to investigate the binding densities of [(3)H]SR141716A (a selective antagonist) and [(3)H]CP-55940 (an agonist) to the CB1 receptors in the STG. Post-mortem brain tissue was obtained from the NSW Tissue Resource Centre (Australia). RESULTS: Contrasting to previous findings in the alterations of CB1 receptor densities in the prefrontal, anterior and posterior cingulate cortex of schizophrenia, which were suggested to be associated to impairment of cognition function, no significant difference was found between the schizophrenia and control cases in both [(3)H]SR141716A and [(3)H]CP-55940 binding. CONCLUSION: We suggest that CB1 receptors in the STG are not involved in the pathology of schizophrenia and the auditory hallucination symptom of this disease.
Authors: D A Silbersweig; E Stern; C Frith; C Cahill; A Holmes; S Grootoonk; J Seaward; P McKenna; S E Chua; L Schnorr Journal: Nature Date: 1995-11-09 Impact factor: 49.962
Authors: Mohini Ranganathan; Jose Cortes-Briones; Rajiv Radhakrishnan; Halle Thurnauer; Beata Planeta; Patrick Skosnik; Hong Gao; David Labaree; Alexander Neumeister; Brian Pittman; Toral Surti; Yiyun Huang; Richard E Carson; Deepak Cyril D'Souza Journal: Biol Psychiatry Date: 2015-08-29 Impact factor: 13.382
Authors: N R Sciolino; M Bortolato; S A Eisenstein; J Fu; F Oveisi; A G Hohmann; D Piomelli Journal: Neuroscience Date: 2010-04-13 Impact factor: 3.590
Authors: Kimberly J Jenko; Jussi Hirvonen; Ioline D Henter; Kacey B Anderson; Sami S Zoghbi; Thomas M Hyde; Amy Deep-Soboslay; Robert B Innis; Joel E Kleinman Journal: Schizophr Res Date: 2012-08-19 Impact factor: 4.939
Authors: Leyre Urigüen; M Julia García-Fuster; Luis F Callado; Benito Morentin; Romano La Harpe; Vicent Casadó; Carmen Lluis; Rafael Franco; Jesús A García-Sevilla; J Javier Meana Journal: Psychopharmacology (Berl) Date: 2009-08-04 Impact factor: 4.530
Authors: Eva M Marco; María S García-Gutiérrez; Francisco-Javier Bermúdez-Silva; Fabricio A Moreira; Francisco Guimarães; Jorge Manzanares; María-Paz Viveros Journal: Front Behav Neurosci Date: 2011-10-05 Impact factor: 3.558
Authors: Leonora E Long; Rose Chesworth; Xu-Feng Huang; Alexander Wong; Adena Spiro; Iain S McGregor; Jonathon C Arnold; Tim Karl Journal: PLoS One Date: 2012-04-03 Impact factor: 3.240