OBJECTIVES: To assess the exposure-response relationship between exposure to quartz and fatal silicosis. METHODS: The mortality from silicosis in 7729 miners was analyzed and compared to their estimated exposure to respirable quartz. The miners had been working as a miner for at least 1 year between 1923 and 1996. Their mortality between 1952 and 2001 was studied by using information from the national cause of death register. Both underlying and contributing causes of death were considered in the analysis. The exposure to quartz was estimated from job titles and using 3239 measurements of personal exposure to respirable quartz from 1965 to 1999. The mortality rates were adjusted to attained age and years of birth using a Poisson regression. RESULTS: The median cumulative exposure among the 7729 miners was 0.9 mg x years m(-3). There were 58 deaths from silicosis. Their median cumulative exposure was 4.8 mg x years m(-3). The crude mortality rate was 53 cases per 100,000 person-years with an exposure-response relationship. CONCLUSION: There seems to be an increased risk of fatal silicosis at exposure levels around 3 mg x years m(-3) for respirable quartz.
OBJECTIVES: To assess the exposure-response relationship between exposure to quartz and fatal silicosis. METHODS: The mortality from silicosis in 7729 miners was analyzed and compared to their estimated exposure to respirable quartz. The miners had been working as a miner for at least 1 year between 1923 and 1996. Their mortality between 1952 and 2001 was studied by using information from the national cause of death register. Both underlying and contributing causes of death were considered in the analysis. The exposure to quartz was estimated from job titles and using 3239 measurements of personal exposure to respirable quartz from 1965 to 1999. The mortality rates were adjusted to attained age and years of birth using a Poisson regression. RESULTS: The median cumulative exposure among the 7729 miners was 0.9 mg x years m(-3). There were 58 deaths from silicosis. Their median cumulative exposure was 4.8 mg x years m(-3). The crude mortality rate was 53 cases per 100,000 person-years with an exposure-response relationship. CONCLUSION: There seems to be an increased risk of fatal silicosis at exposure levels around 3 mg x years m(-3) for respirable quartz.
Authors: Aránzazu Pérez-Alonso; Juan Antonio Córdoba-Doña; José Luis Millares-Lorenzo; Estrella Figueroa-Murillo; Cristina García-Vadillo; José Romero-Morillos Journal: Int J Occup Environ Health Date: 2014 Jan-Mar
Authors: Lei Han; Qianqian Gao; Jingjin Yang; Qiuyun Wu; Baoli Zhu; Hengdong Zhang; Bangmei Ding; Chunhui Ni Journal: Int J Environ Res Public Health Date: 2017-05-06 Impact factor: 3.390
Authors: Veruscka Leso; Luca Fontana; Rosaria Romano; Paola Gervetti; Ivo Iavicoli Journal: Int J Environ Res Public Health Date: 2019-02-16 Impact factor: 3.390
Authors: Mar Requena-Mullor; Raquel Alarcón-Rodríguez; Tesifón Parrón-Carreño; Jose Joaquín Martínez-López; David Lozano-Paniagua; Antonio F Hernández Journal: Int J Environ Res Public Health Date: 2021-05-25 Impact factor: 3.390