Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Crystal structure of the human laminin receptor precursor.

Literature DB >> 18063583

Crystal structure of the human laminin receptor precursor.

Kelly V Jamieson¹, Jinhua Wu², Stevan R Hubbard³, Daniel Meruelo⁴.

Abstract

The human laminin receptor (LamR) interacts with many ligands, including laminin, prions, Sindbis virus, and the polyphenol (-)-epigallocatechin-3-gallate (EGCG), and has been implicated in a number of diseases. LamR is overexpressed on tumor cells, and targeting LamR elicits anti-cancer effects. Here, we report the crystal structure of human LamR, which provides insights into its function and should facilitate the design of novel therapeutics targeting LamR.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2007 PMID： 18063583 DOI： 10.1074/jbc.C700206200

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

Keyword Cloud
Cited

23 in total

1. Conformational switch of a flexible loop in human laminin receptor determines laminin-1 interaction.

Authors: Carmen Di Giovanni; Alessandro Grottesi; Antonio Lavecchia
Journal: Eur Biophys J Date: 2012-03 Impact factor: 1.733

2. Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models.

Authors: Carlos J Orihuela; Jafar Mahdavi; Justin Thornton; Beth Mann; Karl G Wooldridge; Noha Abouseada; Neil J Oldfield; Tim Self; Dlawer A A Ala'Aldeen; Elaine I Tuomanen
Journal: J Clin Invest Date: 2009-05-11 Impact factor: 14.808

Review 3. Structure-guided identification of a laminin binding site on the laminin receptor precursor.

Authors: Kelly V Jamieson; Stevan R Hubbard; Daniel Meruelo
Journal: J Mol Biol Date: 2010-10-30 Impact factor: 5.469

Review 4. Looking into laminin receptor: critical discussion regarding the non-integrin 37/67-kDa laminin receptor/RPSA protein.

Authors: Vincent DiGiacomo; Daniel Meruelo
Journal: Biol Rev Camb Philos Soc Date: 2015-01-28

Crystal structure of the human laminin receptor precursor.

1. Conformational switch of a flexible loop in human laminin receptor determines laminin-1 interaction.

2. Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models.

Review 3. Structure-guided identification of a laminin binding site on the laminin receptor precursor.

Review 4. Looking into laminin receptor: critical discussion regarding the non-integrin 37/67-kDa laminin receptor/RPSA protein.

5. The Transition of the 37-Kda Laminin Receptor (Rpsa) to Higher Molecular Weight Species: Sumoylation or Artifact?

6. Comprehensive proteomic analysis of nonintegrin laminin receptor interacting proteins.

7. Interactions between laminin receptor and the cytoskeleton during translation and cell motility.

8. The laminin-binding protein Lbp from Streptococcus pyogenes is a zinc receptor.

9. Structural Analysis of Nonapeptides Derived from Elastin.

10. Interactions of the 67 kDa laminin receptor and its precursor with laminin.