| Literature DB >> 18063293 |
R D Portugal1, M G P Land, B F Svaiter.
Abstract
Telomere shortening provides a molecular basis for the Hayflick limit. Recent data suggest that telomere shortening also influence mitotic rate. We propose a stochastic growth model of this phenomena, assuming that cell division in each time interval is a random process which probability decreases linearly with telomere shortening. Computer simulations of the proposed stochastic telomere-regulated model provides good approximation of the qualitative growth of cultured human mesenchymal stem cells.Entities:
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Year: 2007 PMID： 18063293 DOI： 10.1016/j.biosystems.2007.10.003
Source DB: PubMed Journal: Biosystems ISSN： 0303-2647 Impact factor: 1.973