| Literature DB >> 18061880 |
Balaji M Agoram1, Steven W Martin, Piet H van der Graaf.
Abstract
Lack of predictability of clinical efficacy and safety is an important problem facing pharmaceutical research today. Translational PK-PD has the ability to integrate data generated from diverse test platforms during discovery and development in a mechanistic framework. Therefore, successful implementation of translational PK-PD modelling and simulation early in the development cycle could have a substantial impact on overall efficiency and success of pharmaceutical research. Three case studies are presented, which outline successful implementation of the translational PK-PD methodology in the rational development of biotherapeutics across various stages of discovery and development. Emerging developments within the field are also discussed.Mesh：
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Year: 2007 PMID： 18061880 DOI： 10.1016/j.drudis.2007.10.002
Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851