Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 VEGF as a potential target for therapeutic intervention in depression.

Literature DB >> 18061540

VEGF as a potential target for therapeutic intervention in depression.

Jennifer L Warner-Schmidt¹, Ronald S Duman.

Abstract

Antidepressants are among the most widely prescribed drugs, however the mechanism underlying their therapeutic efficacy is not known. Neurotrophic factors represent a promising class of targets for antidepressant treatments. We recently characterized a role for vascular endothelial growth factor (VEGF) in cellular and behavioral antidepressant responses. VEGF is a potent mitogen and survival factor for endothelial cells (ECs) and neurons, and modulator of synaptic transmission. Because VEGF has been implicated in a variety of diseases, understanding the molecular and cellular specificity of antidepressant-induced VEGF will be crucial to determine its potential as a therapeutic target in depression.

Entities: Disease Gene

Mesh：

Substances：

Year: 2007 PMID： 18061540 PMCID： PMC2259283 DOI： 10.1016/j.coph.2007.10.013

Source DB: PubMed Journal: Curr Opin Pharmacol ISSN： 1471-4892 Impact factor: 5.547

50 in total

1. Vascular niche for adult hippocampal neurogenesis.

Authors: T D Palmer; A R Willhoite; F H Gage
Journal: J Comp Neurol Date: 2000-10-02 Impact factor: 3.215

Review 2. Antidepressant effects of exercise: evidence for an adult-neurogenesis hypothesis?

Authors: Carl Ernst; Andrea K Olson; John P J Pinel; Raymond W Lam; Brian R Christie
Journal: J Psychiatry Neurosci Date: 2006-03 Impact factor: 6.186

Review 3. Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment.

Authors: Jennifer L Warner-Schmidt; Ronald S Duman
Journal: Hippocampus Date: 2006 Impact factor: 3.899

4. Vascular endothelial growth factor directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival.

Authors: Tamaki Wada; Jody J Haigh; Masatsugu Ema; Seiji Hitoshi; Radha Chaddah; Janet Rossant; Andras Nagy; Derek van der Kooy
Journal: J Neurosci Date: 2006-06-21 Impact factor: 6.167

5. Running enhances neurogenesis, learning, and long-term potentiation in mice.

Authors: H van Praag; B R Christie; T J Sejnowski; F H Gage
Journal: Proc Natl Acad Sci U S A Date: 1999-11-09 Impact factor: 11.205

Review 6. Hippocampus and contextual fear conditioning: recent controversies and advances.

Authors: S G Anagnostaras; G D Gale; M S Fanselow
Journal: Hippocampus Date: 2001 Impact factor: 3.899

7. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus.

Authors: J E Malberg; A J Eisch; E J Nestler; R S Duman
Journal: J Neurosci Date: 2000-12-15 Impact factor: 6.167

8. Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression.

Authors: Yukihiko Shirayama; Andrew C-H Chen; Shin Nakagawa; David S Russell; Ronald S Duman
Journal: J Neurosci Date: 2002-04-15 Impact factor: 6.167

9. Expression of vascular endothelial growth factor and its receptors in rat neural stem cells.

Authors: Martin H Maurer; Wolf K C Tripps; Robert E Feldmann; Wolfgang Kuschinsky
Journal: Neurosci Lett Date: 2003-07-03 Impact factor: 3.046

10. Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo.

Authors: Kunlin Jin; Yonghua Zhu; Yunjuan Sun; Xiao Ou Mao; Lin Xie; David A Greenberg
Journal: Proc Natl Acad Sci U S A Date: 2002-08-14 Impact factor: 11.205

58 in total

Review 1. Novel insights into lithium's mechanism of action: neurotrophic and neuroprotective effects.

Authors: Jorge A Quiroz; Rodrigo Machado-Vieira; Carlos A Zarate; Husseini K Manji
Journal: Neuropsychobiology Date: 2010-05-07 Impact factor: 2.328

2. From father to offspring: paternal transmission of depressive-like behaviors.

Authors: David M Dietz; Eric J Nestler
Journal: Neuropsychopharmacology Date: 2012-01 Impact factor: 7.853

3. Neurotrophic paths in the treatment of depression.

Authors: Shawn Hayley; Hymie Anisman
Journal: J Psychiatry Neurosci Date: 2013-09 Impact factor: 6.186

Review 4. Review of pharmacological treatment in mood disorders and future directions for drug development.

Authors: Xiaohua Li; Mark A Frye; Richard C Shelton
Journal: Neuropsychopharmacology Date: 2011-09-07 Impact factor: 7.853

5. Adult neuroplasticity: A new “cure” for major depression?

Authors: Paul R. Albert
Journal: J Psychiatry Neurosci Date: 2019-03-01 Impact factor: 6.186

Review 6. Pathogenesis of depression: Insights from human and rodent studies.

Authors: C Ménard; G E Hodes; S J Russo
Journal: Neuroscience Date: 2015-05-30 Impact factor: 3.590

7. Paternal transmission of stress-induced pathologies.

Authors: David M Dietz; Quincey Laplant; Emily L Watts; Georgia E Hodes; Scott J Russo; Jian Feng; Ronald S Oosting; Vincent Vialou; Eric J Nestler
Journal: Biol Psychiatry Date: 2011-06-16 Impact factor: 13.382

Review 8. Regulation of inflammation and T cells by glycogen synthase kinase-3: links to mood disorders.

Authors: Eleonore Beurel
Journal: Neuroimmunomodulation Date: 2014-02-14 Impact factor: 2.492

Review 9. VEGF ligands and receptors: implications in neurodevelopment and neurodegeneration.

Authors: Peter Carmeliet; Carmen Ruiz de Almodovar; Ruiz de Almodovar Carmen
Journal: Cell Mol Life Sci Date: 2013-03-12 Impact factor: 9.261

10. Stress and depression: preclinical research and clinical implications.

Authors: Alessandro Bartolomucci; Rosario Leopardi
Journal: PLoS One Date: 2009-01-30 Impact factor: 3.240