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Literature DB >> 18061425

The primary cilia, a 'Rab-id' transit system for hedgehog signaling.

Abstract

Intense focus has been centered around how the primary cilia transduces the hedgehog (Hh) signal from smoothened (Smo) to the Gli transcription factors. New data indicate that ligand and signaling lipids help regulate small GTPase-dependent accumulation and activity of signaling components.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2007 PMID： 18061425 PMCID： PMC3761365 DOI： 10.1016/j.ceb.2007.10.008

Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382

46 in total

Review 1. Hedgehog signaling: Costal-2 bridges the transduction gap.

Authors: Daniel Kalderon
Journal: Curr Biol Date: 2004-01-20 Impact factor: 10.834

2. Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway.

Authors: J T Eggenschwiler; E Espinoza; K V Anderson
Journal: Nature Date: 2001-07-12 Impact factor: 49.962

Review 3. Cilia and developmental signaling.

Authors: Jonathan T Eggenschwiler; Kathryn V Anderson
Journal: Annu Rev Cell Dev Biol Date: 2007 Impact factor: 13.827

4. Vertebrate Smoothened functions at the primary cilium.

Authors: Kevin C Corbit; Pia Aanstad; Veena Singla; Andrew R Norman; Didier Y R Stainier; Jeremy F Reiter
Journal: Nature Date: 2005-08-31 Impact factor: 49.962

5. Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development.

Authors: Miao-Hsueh Chen; Nan Gao; Takatoshi Kawakami; Pao-Tien Chuang
Journal: Mol Cell Biol Date: 2005-08 Impact factor: 4.272

Review 6. Arf-like GTPases: not so Arf-like after all.

Authors: Christopher G Burd; Todd I Strochlic; Subba R Gangi Setty
Journal: Trends Cell Biol Date: 2004-12 Impact factor: 20.808

7. Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.

Authors: Wensheng Zhang; Yun Zhao; Chao Tong; Gelin Wang; Bing Wang; Jianhang Jia; Jin Jiang
Journal: Dev Cell Date: 2005-02 Impact factor: 12.270

Review 8. Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: insights from vesicle recycling in nerve terminals.

Authors: Markus R Wenk; Pietro De Camilli
Journal: Proc Natl Acad Sci U S A Date: 2004-05-14 Impact factor: 11.205

The primary cilia, a 'Rab-id' transit system for hedgehog signaling.

Review 1. Hedgehog signaling: Costal-2 bridges the transduction gap.

2. Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway.

Review 3. Cilia and developmental signaling.

4. Vertebrate Smoothened functions at the primary cilium.

5. Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development.

Review 6. Arf-like GTPases: not so Arf-like after all.

7. Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.

Review 8. Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: insights from vesicle recycling in nerve terminals.

9. The ciliary necklace. A ciliary membrane specialization.

10. Functional dissection of Rab GTPases involved in primary cilium formation.

1. Activation of Erk by sonic hedgehog independent of canonical hedgehog signalling.

2. Primary cilia modulate Ihh signal transduction in response to hydrostatic loading of growth plate chondrocytes.

Review 3. Mechanism and evolution of cytosolic Hedgehog signal transduction.

4. Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved.

Review 5. The Oak Ridge Polycystic Kidney mouse: modeling ciliopathies of mice and men.

Review 6. Therapeutic targets of triple-negative breast cancer: a review.

Review 7. Hedgehog signalling in breast cancer.

8. Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling.

Review 9. The Hedgehog signal transduction network.

10. Glis3 is associated with primary cilia and Wwtr1/TAZ and implicated in polycystic kidney disease.