| Literature DB >> 18061225 |
Laxminarain Misra1, Payare Lal, Narayan D Chaurasia, Rajender S Sangwan, Sudhir Sinha, Rakesh Tuli.
Abstract
2-Mercaptoethanol reacts selectively with the 5beta,6beta-epoxy steroids isolated from Withania somnifera substituting the epoxide by a six-membered oxyethylene-2'-thio ring whereas it failed to show such reactivity on 6alpha,7alpha-epoxy withasteroids. The structure of the product has been elucidated by spectroscopic methods, especially applying extensive 2D NMR methods. The anticancer activity of withaferin A was lost in the reaction product indicating that its activity is also linked to the free 5beta,6beta-epoxide functional group.Entities:
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Year: 2007 PMID： 18061225 DOI： 10.1016/j.steroids.2007.10.006
Source DB: PubMed Journal: Steroids ISSN： 0039-128X Impact factor: 2.668