OBJECTIVE: Women who deliver preterm infants may be at increased risk for cardiovascular disease, perhaps related to dyslipidemia. STUDY DESIGN: In a nested case control study of women with spontaneous preterm birth, cholesterol, high-density lipoprotein, low-density lipoprotein, and triglycerides were evaluated. Lipid concentrations and gestational changes, as well as risk for preterm birth, were evaluated in women who delivered <34 (n = 23), >or=34-<37 (n = 67), and >or=37 weeks (n = 199). RESULTS: High cholesterol or triglycerides <or=15 weeks were associated with a 2.8-fold (1.0-7.9) and 2.0-fold (1.0-3.9) increased risk for preterm birth <34 weeks and >or=34-<37 weeks, respectively. Overweight women who delivered <34 weeks had particularly elevated early pregnancy concentrations of cholesterol and low-density lipoprotein; lean women with moderate preterm birth had elevated triglycerides. There was a reduced triglyceride response in the first half of pregnancy among women who delivered <34 weeks. CONCLUSION: Our results indicate the presence of dyslipidemia in women with spontaneous preterm birth.
OBJECTIVE:Women who deliver preterm infants may be at increased risk for cardiovascular disease, perhaps related to dyslipidemia. STUDY DESIGN: In a nested case control study of women with spontaneous preterm birth, cholesterol, high-density lipoprotein, low-density lipoprotein, and triglycerides were evaluated. Lipid concentrations and gestational changes, as well as risk for preterm birth, were evaluated in women who delivered <34 (n = 23), >or=34-<37 (n = 67), and >or=37 weeks (n = 199). RESULTS: High cholesterol or triglycerides <or=15 weeks were associated with a 2.8-fold (1.0-7.9) and 2.0-fold (1.0-3.9) increased risk for preterm birth <34 weeks and >or=34-<37 weeks, respectively. Overweight women who delivered <34 weeks had particularly elevated early pregnancy concentrations of cholesterol and low-density lipoprotein; lean women with moderate preterm birth had elevated triglycerides. There was a reduced triglyceride response in the first half of pregnancy among women who delivered <34 weeks. CONCLUSION: Our results indicate the presence of dyslipidemia in women with spontaneous preterm birth.
Authors: Janet M Catov; Roberta B Ness; Melissa F Wellons; David R Jacobs; James M Roberts; Erica P Gunderson Journal: J Clin Endocrinol Metab Date: 2010-05-25 Impact factor: 5.958
Authors: Katherine L Grantz; Angelo Elmi; Sarah J Pugh; Janet Catov; Lindsey Sjaarda; Paul S Albert Journal: Am J Perinatol Date: 2019-06-02 Impact factor: 1.862
Authors: S Katherine Laughon; Alexander C McLain; Rajeshwari Sundaram; Janet M Catov; Germaine M Buck Louis Journal: Gynecol Obstet Invest Date: 2013-12-11 Impact factor: 2.031