| Literature DB >> 18060794 |
Pingyu Ding1, Paul Helquist, Marvin J Miller.
Abstract
A siderophore conjugate was designed as a potential PSMA inhibitor and diagnostic agent for prostate cancer. A semi-rigid spacer was incorporated to avoid competitive participation of iron binding by the enzyme inhibitor relative to the siderophore component. Biological test results showed that, even with the extended scaffold, this compound is a potent PSMA inhibitor with an IC50 of 4 nM. This siderophore conjugate may be useful for detection of prostate-derived cancer cells by magnetic resonance imaging (MRI).Entities:
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Year: 2007 PMID： 18060794 PMCID： PMC2701565 DOI： 10.1016/j.bmc.2007.11.030
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641