Literature DB >> 18060649

The expression of endothelin receptor B in melanoma cells A375 and Sk-mel-1 and the proliferative effects of endothelin 3 on A375 cells.

Nengxing Lin1, Changzheng Huang, Jin Tian, Juan Tao, Jin Zhang, Lingyun Yang, Yan Li, Yeqiang Liu, Siyuan Chen, Guanxin Shen, Jiawen Li, Chunsen Wang, Yating Tu.   

Abstract

In order to investigate the expression of endothelin receptor B (ETR-B) in human malignant melanoma (MM) cells A375 and SK-mel-1 and the proliferative effects of endothelin 3 (ET3) on A375 cells, RT-PCR was applied to detect the expression of ETR-B gene in human MM cells A375 and SK-mel-1. MTT method was used to evaluate the growth enhancing effects of ET3 on A375 cell line in vitro. The results showed that ETR-B gene was expressed in both MM A375 and SK-mel-1 cells. ET3 had stronger ability to enhance the proliferation of A375 cells in vitro in a concentration-dependent manner. It was suggested that ET3/ETR-B might play an important proliferative role in MM.

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Year:  2007        PMID： 18060649     DOI： 10.1007/s11596-007-0535-x

Source DB:  PubMed          Journal:  J Huazhong Univ Sci Technolog Med Sci        ISSN： 1672-0733


  5 in total

Review 1.  Development of melanocyte precursors from the vertebrate neural crest.

Authors:  Elisabeth Dupin; Nicole M Le Douarin
Journal:  Oncogene       Date:  2003-05-19       Impact factor: 9.867

2.  An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo.

Authors:  R Lahav; G Heffner; P H Patterson
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-28       Impact factor: 11.205

3.  Expression of the endothelin-B receptor in pigment cell lesions of the skin. Evidence for its role as tumor progression marker in malignant melanoma.

Authors:  A Demunter; C De Wolf-Peeters; H Degreef; M Stas; J J van den Oord
Journal:  Virchows Arch       Date:  2001-05       Impact factor: 4.064

4.  Human melanoma cells express functional endothelin-1 receptors.

Authors:  J J Yohn; C Smith; T Stevens; T A Hoffman; J G Morelli; D L Hurt; M Yanagisawa; M A Kane; M R Zamora
Journal:  Biochem Biophys Res Commun       Date:  1994-05-30       Impact factor: 3.575

5.  Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons.

Authors:  A G Baynash; K Hosoda; A Giaid; J A Richardson; N Emoto; R E Hammer; M Yanagisawa
Journal:  Cell       Date:  1994-12-30       Impact factor: 41.582
  5 in total
  2 in total

1.  Rendomab B4, a monoclonal antibody that discriminates the human endothelin B receptor of melanoma cells and inhibits their migration.

Authors:  Aurélie Borrull; Bertrand Allard; Anne Wijkhuisen; Amaury Herbet; Patricia Lamourette; Wided Birouk; Denis Leiber; Zahra Tanfin; Frédéric Ducancel; Didier Boquet; Jean-Yves Couraud; Philippe Robin
Journal:  MAbs       Date:  2016-07-08       Impact factor: 5.857

2.  Silencing endothelin-3 expression attenuates the malignant behaviors of human melanoma cells by regulating SPARC levels.

Authors:  Xiang-Jie An; Yan-Qiu Li; Xiao-Ying Qu; Jing Zhang; Ling-Yun Zhang; Ming Wang; Li Zhu; Si-Yuan Chen; Hong-Xiang Chen; Ya-Ting Tu; Yu-Wen Zhou; Chang-Zheng Huang
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2013-08-01
  2 in total

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