Literature DB >> 18060371

Alterations in the expression of signal-transducing CD3 zeta chain in T cells from patients with chronic inflammatory/autoimmune diseases.

Lidia Ciszak1, Edyta Pawlak, Agata Kosmaczewska, Stanisław Potoczek, Irena Frydecka.   

Abstract

The CD3 zeta chain, a component of the T cell receptor (TCR)/CD3 complex, is considered to be a limiting factor in the assembly and transport of the TCR/CD3 complex to the cell surface and is crucial to receptor signaling function. Recent studies have demonstrated altered expression and function of this signal transduction molecule in T and natural killer cells in patients with chronic inflammatory/autoimmune diseases. In this review, current knowledge concerning the expression of CD3 zeta chain as well as the mechanisms responsible for abnormal expression of this molecule in systemic lupus erythematosus, rheumatoid arthritis, and childhood idiopathic nephrotic syndrome are summarized.

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Year:  2007        PMID： 18060371     DOI： 10.1007/s00005-007-0042-6

Source DB:  PubMed          Journal:  Arch Immunol Ther Exp (Warsz)        ISSN： 0004-069X            Impact factor:   4.291


  9 in total

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Journal:  Clin Vaccine Immunol       Date:  2010-12-22

2.  Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?

Authors:  Thomas E Ichim; Boris Minev; Todd Braciak; Brandon Luna; Ron Hunninghake; Nina A Mikirova; James A Jackson; Michael J Gonzalez; Jorge R Miranda-Massari; Doru T Alexandrescu; Constantin A Dasanu; Vladimir Bogin; Janis Ancans; R Brian Stevens; Boris Markosian; James Koropatnick; Chien-Shing Chen; Neil H Riordan
Journal:  J Transl Med       Date:  2011-03-04       Impact factor: 5.531

3.  Zeta chain expression in T and NK cells in peripheral blood of children with nephrotic syndrome.

Authors:  Kinga Musiał; Lidia Ciszak; Agata Kosmaczewska; Aleksandra Szteblich; Irena Frydecka; Danuta Zwolińska
Journal:  Pediatr Nephrol       Date:  2009-10-15       Impact factor: 3.714

4.  Covert operations: cancer's many subversive tactics in overcoming host defenses.

Authors:  Dan L Longo
Journal:  Trans Am Clin Climatol Assoc       Date:  2013

5.  Downregulation of CD3ζ in NK Cells from Systemic Lupus Erythematosus Patients Confers a Proinflammatory Phenotype.

Authors:  Abel Suárez-Fueyo; Sean J Bradley; Takayuki Katsuyama; Sarah Solomon; Eri Katsuyama; Vasileios C Kyttaris; Vaishali R Moulton; George C Tsokos
Journal:  J Immunol       Date:  2018-03-30       Impact factor: 5.422

Review 6.  Promising Therapeutic Targets for Treatment of Rheumatoid Arthritis.

Authors:  Jie Huang; Xuekun Fu; Xinxin Chen; Zheng Li; Yuhong Huang; Chao Liang
Journal:  Front Immunol       Date:  2021-07-09       Impact factor: 7.561

7.  Altered expression of the TCR signaling related genes CD3 and FcεRIγ in patients with aplastic anemia.

Authors:  Bo Li; Sichu Liu; Yuzhe Niu; Su Fang; Xiuli Wu; Zhi Yu; Shaohua Chen; Lijian Yang; Yangqiu Li
Journal:  J Hematol Oncol       Date:  2012-03-08       Impact factor: 17.388

8.  Defects at the Posttranscriptional Level Account for the Low TCRζ Chain Expression Detected in Gastric Cancer Independently of Caspase-3 Activity.

Authors:  Ana Aguinaga-Barrilero; Patricia Castro-Sánchez; Ignacio Juárez; Alberto Gutiérrez-Calvo; Noelia Rodríguez-Pérez; Adela Lopez; Remedios Gómez; José M Martin-Villa
Journal:  J Immunol Res       Date:  2020-11-28       Impact factor: 4.818

Review 9.  Antigen receptor signaling in the rheumatic diseases.

Authors:  Julie Zikherman; Arthur Weiss
Journal:  Arthritis Res Ther       Date:  2009-01-30       Impact factor: 5.156
  9 in total

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