Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Interleukin 2: from immunostimulation to immunoregulation and back again.

Literature DB >> 18059313

Interleukin 2: from immunostimulation to immunoregulation and back again.

Abstract

Interleukin 2 (IL-2) was one of the first cytokines to be discovered. However, the complex role of IL-2 and its receptor in the regulation of immune responses is only now emerging. This review explores the various signals triggered by IL-2 and discusses their translation into biological function. A model is outlined that accommodates the seemingly contradictory functions of IL-2, and explains how one cytokine can be an essential T-cell growth and differentiation factor and yet also be indispensable to maintain peripheral tolerance.

Entities: Gene

Mesh：

Substances：
Interleukin-2

Year: 2007 PMID： 18059313 PMCID： PMC2267244 DOI： 10.1038/sj.embor.7401099

Source DB: PubMed Journal: EMBO Rep ISSN： 1469-221X Impact factor: 8.807

83 in total

1. Signals from CD28 induce stable epigenetic modification of the IL-2 promoter.

Authors: Rajan M Thomas; Ling Gao; Andrew D Wells
Journal: J Immunol Date: 2005-04-15 Impact factor: 5.422

2. Recall proliferation potential of memory CD8+ T cells and antiviral protection.

Authors: Martin F Bachmann; Petra Wolint; Katrin Schwarz; Annette Oxenius
Journal: J Immunol Date: 2005-10-01 Impact factor: 5.422

3. Epigenetic remodeling of the IL-2 and IFN-gamma loci in memory CD8 T cells is influenced by CD4 T cells.

Authors: John K Northrop; Rajan M Thomas; Andrew D Wells; Hao Shen
Journal: J Immunol Date: 2006-07-15 Impact factor: 5.422

Review 4. Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis.

Authors: Averil Ma; Rima Koka; Patrick Burkett
Journal: Annu Rev Immunol Date: 2006 Impact factor: 28.527

5. Differential regulation of T-cell growth by IL-2 and IL-15.

Authors: Georgina H Cornish; Linda V Sinclair; Doreen A Cantrell
Journal: Blood Date: 2006-03-28 Impact factor: 22.113

6. Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling.

Authors: Louise M D'Cruz; Ludger Klein
Journal: Nat Immunol Date: 2005-10-16 Impact factor: 25.606

7. A function for interleukin 2 in Foxp3-expressing regulatory T cells.

Authors: Jason D Fontenot; Jeffrey P Rasmussen; Marc A Gavin; Alexander Y Rudensky
Journal: Nat Immunol Date: 2005-10-16 Impact factor: 25.606

8. CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death.

Authors: Edith M Janssen; Nathalie M Droin; Edward E Lemmens; Michael J Pinkoski; Steven J Bensinger; Benjamin D Ehst; Thomas S Griffith; Douglas R Green; Stephen P Schoenberger
Journal: Nature Date: 2005-03-03 Impact factor: 49.962

9. Selective stimulation of T cell subsets with antibody-cytokine immune complexes.

Authors: Onur Boyman; Marek Kovar; Mark P Rubinstein; Charles D Surh; Jonathan Sprent
Journal: Science Date: 2006-02-16 Impact factor: 47.728

10. Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells.

Authors: Matthew A Williams; Aaron J Tyznik; Michael J Bevan
Journal: Nature Date: 2006-06-15 Impact factor: 49.962

74 in total

1. Human Articular Chondrocytes Induce Interleukin-2 Nonresponsiveness to Allogeneic Lymphocytes.

Authors: Satomi Abe; Hitoshi Nochi; Hiroshi Ito
Journal: Cartilage Date: 2016-08-02 Impact factor: 4.634

2. Co-expression of tumor antigen and interleukin-2 from an adenoviral vector augments the efficiency of therapeutic tumor vaccination.

Authors: Benjamin Anderschou Holbech Jensen; Maria Abildgaard Steffensen; Karen Nørgaard Nielsen; Jan Pravsgaard Christensen; Allan Randrup Thomsen; Peter Johannes Holst
Journal: Mol Ther Date: 2014-07-15 Impact factor: 11.454

Review 3. Genetic variation and function of the HIV-1 Tat protein.

Authors: Cassandra Spector; Anthony R Mele; Brian Wigdahl; Michael R Nonnemacher
Journal: Med Microbiol Immunol Date: 2019-03-05 Impact factor: 3.402

4. CLARITY-BPA: Effects of chronic bisphenol A exposure on the immune system: Part 2 - Characterization of lymphoproliferative and immune effector responses by splenic leukocytes.

Authors: Jinpeng Li; Anthony Bach; Robert B Crawford; Ashwini S Phadnis-Moghe; Weimin Chen; Shawna D'Ingillo; Natalia Kovalova; Jose E Suarez-Martinez; Jiajun Zhou; Barbara L F Kaplan; Norbert E Kaminski
Journal: Toxicology Date: 2018-02-07 Impact factor: 4.221

5. Eomesodermin Increases Survival and IL-2 Responsiveness of Tumor-specific CD8+ T Cells in an Adoptive Transfer Model of Cancer Immunotherapy.

Authors: Aki Furusawa; John Reiser; Kavitha Sadashivaiah; Haley Simpson; Arnob Banerjee
Journal: J Immunother Date: 2018 Feb/Mar Impact factor: 4.456

Review 6. Changes of T-cell Immunity Over a Lifetime.

Authors: Yeqi Nian; Koichiro Minami; Ryoichi Maenesono; Jasper Iske; Jinrui Yang; Haruhito Azuma; Abdala ElKhal; Stefan G Tullius
Journal: Transplantation Date: 2019-11 Impact factor: 4.939

Review 7. Early programming and late-acting checkpoints governing the development of CD4 T-cell memory.

Authors: Kunal Dhume; Karl Kai McKinstry
Journal: Immunology Date: 2018-05-21 Impact factor: 7.397

Review 8. Immunotherapy of advanced renal cell carcinoma: Current and future therapies.

Authors: David Gill; Andrew W Hahn; Guru Sonpavde; Neeraj Agarwal
Journal: Hum Vaccin Immunother Date: 2016-08-05 Impact factor: 3.452

9. Splicing factor SF2/ASF rescues IL-2 production in T cells from systemic lupus erythematosus patients by activating IL-2 transcription.

Authors: Vaishali R Moulton; Alexandros P Grammatikos; Lisa M Fitzgerald; George C Tsokos
Journal: Proc Natl Acad Sci U S A Date: 2013-01-14 Impact factor: 11.205

Review 10. Anti-viral CD8 T cells and the cytokines that they love.

Authors: Maureen A Cox; Shannon M Kahan; Allan J Zajac
Journal: Virology Date: 2013-01-05 Impact factor: 3.616