Literature DB >> 1805801

Effects of thiamine deficiency on the secretion of insulin and the metabolism of glucose in isolated rat pancreatic islets.

P Rathanaswami1, A Pourany, R Sundaresan.   

Abstract

Isolated pancreatic islets from thiamine deficient rats secrete less insulin. The secretion of insulin in response to glucose and tolbutamide is also decreased in these islets. Glucose and pyruvate oxidations to CO2, were decreased in the islets isolated from thiamine deficient rats. In the islets from control but not from thiamine deficient rats the oxidations of glucose and pyruvate to CO2 were increased by tolbutamide. The results suggest that in thiamine deficiency the insulin secretion is impaired due to the decreased glucose oxidation.

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Year:  1991        PMID： 1805801

Source DB:  PubMed          Journal:  Biochem Int        ISSN： 0158-5231


  24 in total

1.  Chronic alcohol exposure affects pancreatic acinar mitochondrial thiamin pyrophosphate uptake: studies with mouse 266-6 cell line and primary cells.

Authors:  Padmanabhan Srinivasan; Svetlana Nabokina; Hamid M Said
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2015-08-27       Impact factor: 4.052

2.  The effects of dietary thiamin on oxidative damage and antioxidant defence of juvenile fish.

Authors:  Xue-Yin Li; Hui-Hua Huang; Kai Hu; Yang Liu; Wei-Dan Jiang; Jun Jiang; Shu-Hong Li; Lin Feng; Xiao-Qiu Zhou
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3.  Relative contribution of THTR-1 and THTR-2 in thiamin uptake by pancreatic acinar cells: studies utilizing Slc19a2 and Slc19a3 knockout mouse models.

Authors:  Veedamali S Subramanian; Sandeep B Subramanya; Hamid M Said
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2011-12-22       Impact factor: 4.052

4.  Polymeric gene transfection on insulin-secreting cells: sulfonylurea receptor-mediation and transfection medium effect.

Authors:  Han Chang Kang; You Han Bae
Journal:  Pharm Res       Date:  2006-08       Impact factor: 4.200

5.  Adaptive regulation of pancreatic acinar mitochondrial thiamin pyrophosphate uptake process: possible involvement of epigenetic mechanism(s).

Authors:  Subrata Sabui; Veedamali S Subramanian; Rubina Kapadia; Hamid M Said
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2017-07-20       Impact factor: 4.052

6.  Mechanisms involved in the inhibitory effect of chronic alcohol exposure on pancreatic acinar thiamin uptake.

Authors:  Padmanabhan Srinivasan; Veedamali S Subramanian; Hamid M Said
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2014-02-13       Impact factor: 4.052

7.  Effects of combined dietary chromium(III) propionate complex and thiamine supplementation on insulin sensitivity, blood biochemical indices, and mineral levels in high-fructose-fed rats.

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Journal:  Biol Trace Elem Res       Date:  2012-10-16       Impact factor: 3.738

8.  Inhibition of pancreatic acinar mitochondrial thiamin pyrophosphate uptake by the cigarette smoke component 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

Authors:  Padmanabhan Srinivasan; Edwin C Thrower; Fred S Gorelick; Hamid M Said
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2016-03-17       Impact factor: 4.052

9.  Pancreatic beta cells and islets take up thiamin by a regulated carrier-mediated process: studies using mice and human pancreatic preparations.

Authors:  Lisa Mee; Svetlana M Nabokina; V Thillai Sekar; Veedamali S Subramanian; Kathrin Maedler; Hamid M Said
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2009-05-07       Impact factor: 4.052

Review 10.  Recent advances in transport of water-soluble vitamins in organs of the digestive system: a focus on the colon and the pancreas.

Authors:  Hamid M Said
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2013-08-29       Impact factor: 4.052
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